Kingfisher Biotech Circular
IL-34: The brains behind CSF-1R pathology in the brain and skin?

In humans, loss or gain of function in CSF-1R has been associated with many inflammatory conditions and cancers, due to its role in the maintenance of mononuclear phagocytes. In particular, the CSF-1R ligand IL-34 plays a key role in maintaining the tissue resident macrophages of the skin and brain, thus being critical to antimicrobial and other inflammatory responses at these sites. IL-34, along with CSF-1, has also been implicated in the inflammation of rheumatoid arthritis and Sjögrens, as well as a poor prognosis in many malignancies. more...

Kingfisher Biotech Circular
Context is critical for the pivotal functions of Interleukin-6

Interleukin-6 (IL-6), once known as interferon-beta 2, has long been studied for its role in pro-inflammatory responses, notably the acute phase response and B cell maturation. However, the vastly pleiotropic functions of IL-6 have begun to be appreciated, including an anti-inflammatory role for IL-6 as a myokine in response to physical stress. To achieve such different outcomes a complex interplay is required between various cytokines, receptors and signaling pathways, much of which still requires elaboration. For instance, IL-6 can be recognized by either a surface or soluble IL-6 receptor. Evolutionary conservation of distant piscine orthologs, associations with a wide assortment of autoimmune disorders and cancers, and the availability of monoclonal antibody therapies targeting both IL-6 and IL-6R further emphasize the importance of understanding this multifunctional cytokine. more...

Antibody Cross-reactivity

Many of our antibodies work across species. Check out our antibody cross-reactivity tables to find the antibody that works with your specie. We have two tables - one for our antibodies to cytokines and one for our antibodies to cell surface markers.

Do-It-Yourself ELISAs

Kingfisher Biotech offers over 90 pairs of antibodies and proteins across eleven species that have been shown to work in ELISA. Our newest pairs include, Canine IFN alphaMouse TNF alphaMouse VEGF-A, and Swine IL-10.

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Kingfisher Biotech, Inc. is committed to accelerating basic veterinary research and human disease research done in animal models by developing and commercializing research reagents specific for a variety of species. We will continue to add species as our customer request specific reagents for their research. Currently, we offer over 800 reagents and kits for veterinary and animal model research. If there is a product that you are looking for and can't find, please send us an email.

APRIL (TNFSF13)BAFF (TNFSF13B)CCL2 (MCP-1)CCL3 (MIP-1 alpha)CCL3L1CCL4 (MIP-1 beta)CCL5 (RANTES)CCL11 (Eotaxin)CCL20CXCL1 (GRO alpha)CXCL9 (MIG)CXCL10 (IP-10)CXCL11 (I-TAC)CXCL12FGF basicGM-CSFIFN alphaIFN betaIFN gammaIGF-1IGF-2IL-1 alphaIL-1 betaIL-1F5IL-1 receptor antagonistIL-2IL-4IL-5IL-6IL-8 (CXCL8)IL-10IL-12 p40IL-13IL-15IL-16,IL-17AIL-17FIL-18IL-21IL-22IL-23AIL-24M-CSFMIFRANKL (TNFSF11)SCF,TNF alphaTNFSF15 (TL1A)TWEAKVEGF-A

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