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Bovine IFN beta Polyclonal Antibody

PB0444B-100
$380.00
In Stock
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Type I interferons (IFN alpha, IFN beta) belong to the helical cytokine superfamily, which includes growth hormones, interleukins, several colony-stimulating factors plus other regulatory molecules. All function as regulators of cellular activity by interacting with cell-surface receptors and activating various signaling pathways. IFN beta produces antiviral, antibacterial, and anticancer properties. RANKL (TNFSF11) has been shown to induce the production of IFN beta.

Reactivity - ELISA
Bovine IFN beta - Strong
Equine IFN beta - Weak
Mouse IFN beta - Weak
Swine IFN beta - None

Bovine IFN beta ELISA Data
Bovine IFN beta Standard Curve

 

 

Catalog No.:
PB0444B-100
Quantity:
100 ug
Country of Origin:
USA
Host:
The bovine IFN beta polyclonal antibody was produced in goats.
Purification:
Antigen-affinity Purification
Immunogen:
Recombinant Bovine IFN beta
Applications:
The bovine IFN beta polyclonal antibody has been qualified for use in Western Blot and ELISA applications.

32411730

Increased Susceptibility of Cattle to Intranasal RVFV Infection.

Kroeker AL, Smid V, Embury-Hyatt C, Collignon B, Pinette M, Babiuk S, Pickering B.

Front Vet Sci. 2020 Apr 29;7:137. doi: 10.3389/fvets.2020.00137. eCollection 2020.

Applications: Measurement of bovine IFN alpha and IFN beta in nasal and oral swabs by ELISA.

Abstract

Rift Valley Fever virus (RVFV) is a zoonotic mosquito-borne virus that belongs to the Phenuiviridae family. Infections in animal herds cause abortion storms, high mortality rates in neonates, and mild to severe symptoms. Infected animals can also transmit the virus to people, particularly people who live or work in close contact with livestock. There is currently an ongoing effort to produce safe and efficacious veterinary vaccines against RVFV in livestock to protect against both primary infection in animals and zoonotic infections in people. To test the efficacy of these vaccines it is essential to have a reliable challenge model in relevant target species, including ruminants. In this study we evaluated three routes of inoculation (intranasal, intradermal and a combination of routes) in Holstein cattle using an infectious dose of 107 pfu/ml and a virus strain from the 2006–2007 outbreak in Kenya and Sudan. Our results demonstrated that all routes of inoculation were effective at producing viremia in all animals; however, the intranasal route induced the highest levels and longest duration of viremia, the most noticeable clinical signs, and the most widespread infection of tissues. We therefore recommend using the intranasal inoculation for future vaccine and challenge studies.


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