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Bovine CCL2 (MCP-1) (Yeast-derived Recombinant Protein) - 500 ug (5 x 100 ug vials)

RP0027B-500
$3300.00
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Bulk quantities of proteins are available. Please contact us for bulk pricing.

Chemokine (C-C motif) ligand 2 (CCL2), also known as monocyte chemotactic protein-1 (MCP-1), is a small cytokine belonging to the CC chemokine family. There are at least 27 distinct members of the C-C subgroup reported for mammals. They are characterized by two adjacent cysteines. CCL2 (MCP-1) recruits monocytes, memory T cells, and dendritic cells to sites of tissue injury and infection. CCL2 (MCP-1) is implicated in pathogeneses of several diseases characterized by monocytic infiltrates, such as psoriasis, rheumatoid arthritis and atherosclerosis.

Alternate Names - CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF, C-C motif chemokine ligand 2

CCL2 Homology Across Species
Bos taurus (cattle) CCL2 – 100%
Bison bison bison (American buffalo) CCL2 – 100%
Bos mutus (wild yak) CCL2 - 100%
Bos indicus (zebu) CCL2 – 100%
Bubalus bubalis (water buffalo) CCL2 – 99%
More - https://blast.ncbi.nlm.nih.gov

Bovine CCL2 (MCP-1) (Yeast-derived Recombinant Protein) - 500 ug (5 x 100 ug vials)
Catalog No.:
RP0027B-500
Quantity:
500 ug (5 x 100 ug vials)
Source:
The Bovine CCL2 (MCP-1) recoombinant protein was produced in yeast and therefore does not have endotoxin, is naturally folded, and post-translationally modified.
MW:
The Bovine CCL2 recombinant protein has a predicted molecular weight of 8.8 kDa.
Protein Sequence:
QPDAINSQVA CCYTFNSKKI SMQRLMNYRR VTSSKCPKEA VIFKTILGKE LCADPKQKWV QDSINYLNKK NQTPKP (76)
Alias:
MCP-1
Country of Origin:
USA
Applications:
The Bovine CCL2 (MCP-1) endotoxin-free recombinant protein can be used in cell culture, as an CCL2/MCP-1 ELISA Standard, and as a Western Blot Control.

32122602

The chemokines CCL2 and CXCL10 produced by bovine endometrial epithelial cells induce migration of bovine B lymphocytes, contributing to transuterine transmission of BLV infection.

Andoh K, Nishimori A, Sakumoto R, Hayashi KG, Hatama S.

Vet Microbiol. 2020 Mar;242:108598. doi: 10.1016/j.vetmic.2020.108598. Epub 2020 Jan 28.

Applications: Measurement of bovine CXCL10 and CCL2 in supernatant of BEnEpCs by ELISA


25427847

Enzyme linked immunosorbent assay for quantification of bovine interleukin-8 to study infection and immunity in the female genital tract.

Cronin JG, Hodges R, Pedersen S, Sheldon IM.

Am J Reprod Immunol. 2015 Apr;73(4):372-82. doi: 10.1111/aji.12344. Epub 2014 Nov 27.

Applications: Bovine IL-8 protein was used as an ELISA standard. Bovine IL-10 and CCL2 were used to check the ELISA for specificity.


25155606

Maternal intravenous administration of azithromycin results in significant fetal uptake in a sheep model of second trimester pregnancy.

Kemp MW, Miura Y, Payne MS, Jobe AH, Kallapur SG, Saito M, Stock SJ, Spiller OB, Ireland DJ, Yaegashi N, Clarke M, Hahne D, Rodger J, Keelan JA, Newnham JP.

Antimicrob Agents Chemother. 2014 Nov;58(11):6581-91. doi: 10.1128/AAC.03721-14. Epub 2014 Aug 25.

Applications: Measurement by ELISA of MCP-2 (CCL2) in sheep amniotic fluid.


24982089

Maternal intravenous treatment with either azithromycin or solithromycin clears Ureaplasma parvum from the amniotic fluid in an ovine model of intrauterine infection.

Miura Y, Payne MS, Keelan JA, Noe A, Carter S, Watts R, Spiller OB, Jobe AH, Kallapur SG, Saito M, Stock SJ, Newnham JP, Kemp MW.

Antimicrob Agents Chemother. 2014 Sep;58(9):5413-20. doi: 10.1128/AAC.03187-14. Epub 2014 Jun 30.

Applications: Measurement by ELISA of MCP-2 (CCL2) in sheep amniotic fluid.


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