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Chicken CCL5 (RANTES) Recombinant Protein
- Catalog Number:
- RP0982C
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Gallus gallus (chicken)
- Chicken CCL5 (RANTES) (catalog RP0982C) is a yeast-derived chemokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~7.8 kDa, 68 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to chicken. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study CCL5/RANTES signaling and immune-cell chemotaxis (including recruitment of T cells, eosinophils, and basophils); typical experimental uses include cell-culture stimulation and migration assays, chemotaxis and signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | SPFGADTTVC CFNYSVRKLP QNHVKDYFYT SSKCPQAAVV FITRKGRQVC ANPDARWVKE YINFLELQ (68) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 7.8 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Chicken CCL5 (C-C motif chemokine ligand 5, also known as RANTES - Regulated upon Activation, Normal T cell Expressed and Secreted) is a proinflammatory chemokine involved in immune cell recruitment and inflammatory responses in chickens (Gallus gallus). CCL5 is a member of the CC chemokine family, which includes related chemokines such as CCL3, CCL4, and CCL2, all of which regulate leukocyte trafficking during immune activation. In chickens, CCL5 is produced primarily by activated T lymphocytes, macrophages, dendritic cells, and epithelial cells in response to infection, inflammatory stimuli, or tissue damage. CCL5 functions mainly by binding to chemokine receptors such as CCR1 and CCR5, triggering intracellular signaling pathways that promote chemotaxis and activation of T cells, monocytes/macrophages, and other immune cells at sites of infection or inflammation. In avian immunity, CCL5 plays a role in responses to viral, bacterial, and parasitic pathogens, including important poultry diseases such as avian influenza virus, Newcastle disease virus, and Eimeria infections, where recruitment of immune cells is critical for pathogen control. Because chickens are widely used in avian immunology and host-pathogen interaction studies, chicken CCL5 is studied in research on chemokine signaling, inflammatory responses, and vaccine-induced immunity, contributing to improved understanding of immune regulation and disease resistance in poultry.
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