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Human CCL5 (RANTES) Recombinant Protein
- Catalog Number:
- RP0983H
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Gorilla gorilla gorilla (western lowland gorilla), Homo sapiens (human), Pan paniscus (pygmy chimpanzee), Pan troglodytes (chimpanzee)
- Human CCL5 (RANTES) (catalog RP0983H) is a yeast-derived chemokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~7.9 kDa, 68 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to human, pygmy chimpanzee, chimpanzee, and western lowland gorilla. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study CCL5/RANTES signaling and immune-cell chemotaxis (including recruitment of T cells, eosinophils, and basophils); typical experimental uses include cell-culture stimulation and migration assays, chemotaxis and signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | SPYSSDTTPC CFAYIARPLP RAHIKEYFYT SGKCSNPAVV FVTRKNRQVC ANPEKKWVRE YINSLEMS (68) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 7.9 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Human CCL5 (C-C motif chemokine ligand 5, also known as RANTES - Regulated upon Activation, Normal T cell Expressed and Secreted) is a proinflammatory chemokine that plays a central role in immune cell recruitment, antiviral defense, and inflammatory signaling. CCL5 belongs to the CC chemokine family, which also includes CCL3 (MIP-1α), CCL4 (MIP-1β), and CCL2 (MCP-1), chemokines that regulate leukocyte trafficking during immune responses. In humans, CCL5 is produced primarily by activated T lymphocytes, macrophages, dendritic cells, platelets, epithelial cells, and endothelial cells in response to infection, inflammatory stimuli, or tissue injury. It exerts its biological effects mainly through binding to the chemokine receptors CCR1, CCR3, and CCR5, triggering intracellular signaling pathways that promote chemotaxis and activation of T cells, monocytes/macrophages, eosinophils, basophils, and natural killer (NK) cells at sites of infection or inflammation. Human CCL5 is involved in immune responses against viral, bacterial, and parasitic pathogens, and dysregulated CCL5 signaling has been implicated in chronic inflammatory and immune-mediated diseases such as asthma, rheumatoid arthritis, multiple sclerosis, and inflammatory bowel disease, as well as in tumor progression and metastasis through effects on the tumor microenvironment. Because CCL5 interacts with CCR5, which is also a key co-receptor for HIV entry, the CCL5-CCR5 signaling pathway has been extensively studied in immunology, infectious disease, cancer biology, and therapeutic development, including the design of CCR5-targeted drugs and immunomodulatory therapies.
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