Cynomolgus Monkey (Macaca fascicularis) CXCL10 (C-X-C motif chemokine ligand 10), also known as IP-10 (Interferon gamma–induced protein 10), is a proinflammatory chemokine belonging to the CXC chemokine family, which also includes CXCL9 (MIG) and CXCL11 (I-TAC) that regulate T-cell recruitment during antiviral and inflammatory immune responses. In cynomolgus monkeys, CXCL10 is produced by macrophages, dendritic cells, epithelial cells, endothelial cells, and fibroblasts in response to interferon-γ (IFN-γ), viral infection, or inflammatory cytokines. CXCL10 signals primarily through the chemokine receptor CXCR3, which is expressed on activated T lymphocytes, natural killer (NK) cells, and other immune cells, promoting chemotaxis and activation of these immune cells at sites of infection or inflammation. Because cynomolgus monkeys share strong genetic and immunological similarity with humans, they are widely used as preclinical animal models for infectious diseases and vaccine development, including studies of SARS-CoV-2, dengue virus, and other viral infections. In these models, CXCL10 expression is associated with interferon-driven immune responses and recruitment of CXCR3⁺ T cells to infected tissues, making cynomolgus monkey CXCL10 an important marker for studying antiviral immunity, immune-mediated inflammation, and evaluation of antiviral therapies and vaccines.