Dolphin CCL2 (C-C motif chemokine ligand 2, also known as monocyte chemoattractant protein-1, MCP-1) is a pro-inflammatory chemokine that regulates recruitment and activation of monocytes, macrophages, and memory T cells during immune responses in dolphins, particularly the bottlenose dolphin (Tursiops truncatus). CCL2 primarily signals through the CCR2 receptor, activating intracellular pathways that promote leukocyte migration, cytokine production, and coordination of innate and adaptive immune responses at sites of infection, inflammation, or tissue injury. In dolphin health, CCL2 is believed to play an important role in inflammatory responses associated with respiratory infections, skin lesions, parasitic disease, and wound healing, where monocyte and macrophage recruitment contributes to pathogen clearance and tissue repair. Dysregulated or prolonged CCL2 expression may contribute to chronic inflammatory conditions or fibrosis, especially in animals exposed to environmental stressors such as pollutants, harmful algal toxins, or infectious outbreaks. Because dolphins are considered sentinel species for marine ecosystem health, CCL2 expression is an important biomarker for studying immune activation, environmental immunotoxicology, and host–pathogen interactions in marine mammals. Characterization of dolphin CCL2 therefore supports research into chemokine-mediated immune regulation, marine wildlife health, and comparative inflammatory biology across mammalian species.