Slide 1 of 1 
Ferret IL-22 ELISA
- Catalog Number:
- DIY1959FT
- Availability:
- In stock
- Application:
- ELISA
- 100% Homology:
- Mustela putorius furo (domestic ferret)
Components
| Usage | Quantity | Component | Size |
|---|---|---|---|
| Detection Antibody | 50 µg | KPB1958FT-050 | |
| Standard | 5 µg | RP1845FT-005 | |
| Capture Antibody | 100 µg | KP1957FT-100 | 1 Pack (<= 10 Plates) |
| Capture Antibody | 100 µg X 2 | KP1957FT-100 | 1 Pack (<= 20 Plates) |
- The Ferret IL-22 ELISA is designed for the quantitative measurement of interleukin-22 (IL-22) in ferret (Mustela putorius furo) cell culture supernatants and can also be used to measure IL-22 in additional biological sample types reported in the literature, including serum, plasma, bronchoalveolar lavage (BAL) fluid, and tissue lysates, with minor protocol modifications recommended to optimize performance across different matrices. IL-22 is a barrier-protective cytokine produced primarily by activated Th17 and Th22 cells, innate lymphoid cells (ILC3), and NK cell subsets, and it signals through the IL-22 receptor complex (IL-22R1 and IL-10R2) expressed mainly on epithelial and stromal cells to promote mucosal defense, antimicrobial peptide production, epithelial proliferation, and tissue repair. In healthy ferrets, circulating IL-22 levels are typically low or near the limit of detection (often <5-10 pg/mL in serum or plasma), but concentrations can increase to tens or hundreds of pg/mL during respiratory viral infection, airway inflammation, mucosal injury, or experimental immune stimulation, depending on disease severity and timing of sampling. In translational and infectious disease research, particularly in ferret respiratory virus models such as influenza and coronaviruses, ferret IL-22 serves as an important biomarker of mucosal immune activation, epithelial barrier responses, and inflammation-associated tissue repair. The ELISA kit contains a capture antibody, detection antibody, and recombinant ferret IL-22 protein standard validated for use together in an ELISA format; kit components are not supplied in matched quantities and may be purchased separately. This product is for research use only, not for use in diagnostic or therapeutic procedures, and is manufactured in the USA.
| Storage Conditions | 2°C to 8°C or -20°C |
| Country Of Origin | USA |
- Ferret IL-22 (Interleukin-22) is a member of the IL-10 cytokine family that plays a key role in mucosal immunity and epithelial barrier protection in ferrets (Mustela putorius furo). IL-22 is produced primarily by activated CD4⁺ T cells, including Th17- and Th22-like populations, as well as by innate lymphoid cells (ILC3s) in response to microbial infection and inflammatory stimulation. It signals through the IL-22 receptor complex (IL-22R1 and IL-10R2), which is expressed mainly on epithelial and stromal cells, activating downstream JAK/STAT pathways-particularly STAT3-to induce antimicrobial peptide production, enhance chemokine expression, promote epithelial cell proliferation, and support tissue repair. In healthy ferrets, basal IL-22 expression is generally low but increases during bacterial, viral, and fungal infections, especially at mucosal surfaces of the respiratory and gastrointestinal tracts. In biomedical research, ferret IL-22 is particularly relevant in respiratory disease models such as influenza and SARS-CoV-2, where it contributes to epithelial defense and tissue regeneration while influencing inflammatory responses. Characterization of IL-22 in ferrets provides insight into mucosal immune regulation, host-pathogen interactions, and the balance between protective immunity and immunopathology in a widely used model of human respiratory infection.
Please choose a size to see price