Bovine CCL8 (C–C motif chemokine ligand 8, also known as MCP-2 – Monocyte Chemoattractant Protein-2) is a proinflammatory chemokine that regulates leukocyte recruitment and inflammatory responses in cattle (Bos taurus). CCL8 belongs to the CC chemokine family, which includes related chemokines such as CCL2 (MCP-1), CCL7 (MCP-3), and CCL13 (MCP-4) that coordinate monocyte and leukocyte trafficking during immune activation. In cattle, CCL8 is produced by macrophages, fibroblasts, endothelial cells, epithelial cells, and other immune cells in response to infection, inflammatory cytokines, or tissue injury. CCL8 exerts its biological effects through interaction with chemokine receptors including CCR1, CCR2, CCR3, and CCR5, promoting chemotaxis and activation of monocytes, macrophages, dendritic cells, T lymphocytes, and eosinophils at sites of infection or inflammation. In bovine health, CCL8 contributes to immune responses against bacterial and viral pathogens, including those involved in mastitis, bovine respiratory disease complex, and other inflammatory conditions, where recruitment of immune cells is essential for pathogen clearance. Because chemokine-mediated leukocyte trafficking is critical for effective host defense, bovine CCL8 is studied in veterinary immunology, infectious disease research, and host–pathogen interaction studies, helping to improve understanding of immune regulation and disease resistance in cattle.