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Canine IL-17A Polyclonal Antibody
- Catalog Number:
- KP0958D
- Availability:
- In stock
- Application:
- ELISA, ELISpot, Flow Cytometry, Neutralization, Western Blot
- Host:
- Rabbit
- 100% Homology:
- Canis lupus dingo (dingo), Canis lupus familiaris (dog), Vulpes lagopus (Arctic fox)
- Label:
- Unconjugated
- Anti-canine IL-17A polyclonal antibody (catalog KP0958D) is made in rabbits, affinity-purified by canine IL-17A affinity chromatography and supplied in PBS containing 0.09% NaN₃; it was raised against recombinant canine IL-17A (immunogen) and the calculated molecular weight of canine IL-17A is ~14.8 kDa. Store at 2-8°C (stable up to 12 months from date of receipt). Recommended working concentrations are Western blot 0.1-2 µg/mL and ELISA 1-5 µg/mL (optimize per assay); typical sandwich ELISA reagent pairings and suggested conditions are provided on the datasheet (capture antibody KP0958D; standard protein RP0920D-005; detection antibody KPB0959D; streptavidin-HRP AR0068-001; TMB substrate AR0133-002). In cross-reactivity testing (ELISA) this antibody shows strong reactivity to human IL-17A and no reactivity to bovine, equine, mouse, ovine, rabbit, rat or swine IL-17A. It is commonly used for ELISA, ELISpot, flow cytometry, neutralization, and Western blot applications (users should validate and optimize conditions for each application). The product is made in the USA, supplied for research applications only, and is not intended for medicinal, diagnostic, or therapeutic use.
| Storage Conditions | 2°C to 8°C |
| Purification | Antigen-affinity |
| Country Of Origin | USA |
- Canine IL-17A (Interleukin-17A) is a pro-inflammatory cytokine belonging to the IL-17 family that plays a central role in host defense and inflammatory responses in dogs (Canis lupus familiaris). IL-17A is produced primarily by Th17 cells, as well as by γδ T cells and other innate lymphoid cell populations, in response to microbial infection and inflammatory stimulation. It acts on epithelial, endothelial, and stromal cells to induce the expression of pro-inflammatory cytokines, chemokines (such as CXCL8), and antimicrobial peptides, thereby promoting neutrophil recruitment and enhancing mucosal and barrier immunity. In healthy dogs, basal IL-17A expression is typically low, but levels increase during bacterial and fungal infections, chronic inflammatory conditions, and immune-mediated diseases. Elevated IL-17A has been implicated in canine atopic dermatitis, inflammatory bowel disease, immune-mediated polyarthritis, chronic rhinitis, and certain autoimmune or inflammatory neurologic disorders. In veterinary and comparative medicine research, canine IL-17A serves as an important biomarker of Th17-mediated immune activation and neutrophilic inflammation, providing insight into disease pathogenesis and potential immunomodulatory therapeutic strategies in canine health.
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