Canine IL-1 beta Polyclonal Antibody

Catalog Number:: KP1015D
Availability:: In stock
Application:: ELISA, ELISpot, Flow Cytometry, Neutralization, Western Blot
Host:: Rabbit
100% Homology:: Canis lupus dingo (dingo), Canis lupus familiaris (dog)
Label:: Unconjugated

Product Description

The Canine IL-1 beta polyclonal antibody is unlabeled and has been qualified for use in ELISA and Western blot applications. It is the capture antibody in the Kingfisher Biotech Canine IL-1 beta ELISA. The Canine IL-1 beta antibody was produced in rabbits and is antigen-affinity purified. The reactivity by species is: (Bovine IL-1beta - None) (Canine IL-1beta - Strong) (Dolphin IL-1beta - None) (Equine IL-1beta - None) (Feline IL-1beta - None) (Guinea Pig IL-1beta - None) (Human IL-1beta - None) (Mouse IL-1beta - None) (Ovine IL-1beta - None) (Rabbit IL-1beta - None) (Swine IL-1beta - None) (Turkey IL-1beta - None). For research use only.

Properties

Storage Conditions	2°C to 8°C
Purification	Antigen-affinity
Country Of Origin	USA

Background Info

Canine Interleukin-1 Beta (IL-1β) is a potent pro-inflammatory cytokine produced primarily by activated macrophages, monocytes, and dendritic cells in dogs (Canis lupus familiaris) following recognition of pathogens or tissue damage. Synthesized as an inactive precursor (pro-IL-1β), it is cleaved into its active form by caspase-1 within the inflammasome complex and subsequently binds to the IL-1 receptor (IL-1R1), activating NF-κB and MAPK signaling pathways that drive fever, leukocyte recruitment, endothelial activation, and acute-phase protein production. In canine health, IL-1β plays a central role in inflammatory and infectious conditions including bacterial pneumonia, pyometra, parvoviral enteritis, osteoarthritis, immune-mediated diseases, and sepsis, where excessive or sustained IL-1β production can contribute to tissue damage and systemic inflammation. Elevated IL-1β levels are also associated with chronic inflammatory disorders and certain cancers, reflecting its role in shaping the tumor microenvironment. As both a biomarker and therapeutic target, canine IL-1β is important in veterinary medicine for monitoring inflammatory status and evaluating anti-inflammatory interventions. In translational research, dogs serve as valuable spontaneous models for human osteoarthritis, inflammatory bowel disease, sepsis, and cancer, and characterization of canine IL-1β supports studies of inflammasome activation, cytokine-driven pathology, and development of targeted immunomodulatory therapies relevant to both canine and human health.

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