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Bovine Leukemia Inhibitory Factor (LIF) Polyclonal Antibody
- Catalog Number:
- KP1041B
- Availability:
- In stock
- Application:
- ELISA, ELISpot, Flow Cytometry, Neutralization, Western Blot
- Host:
- Rabbit
- 100% Homology:
- Bos taurus (cattle)
- Label:
- Unconjugated
- The Bovine Leukemia Inhibitory Factor (LIF) polyclonal antibody is unlabeled and has been qualified for use in ELISA and Western blot applications. It is the capture antibody in the Kingfisher Biotech Bovine Leukemia Inhibitory Factor ELISA. The Bovine Leukemia Inhibitory Factor antibody was produced in chickens and is antigen-affinity purified. The reactivity by species is: (Bovine LIF - Strong) (Canine LIF - Weak) (Rabbit LIF - Moderate) (Swine LIF - Weak). For research use only.
| Storage Conditions | 2°C to 8°C |
| Purification | Antigen-affinity |
| Country Of Origin | USA |
- Bovine Leukemia Inhibitory Factor (LIF) is a multifunctional cytokine belonging to the IL-6 family-which includes IL-6, IL-11, oncostatin M (OSM), ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT-1), cardiotrophin-like cytokine factor 1 (CLCF1), and IL-27-all of which signal through receptor complexes containing the shared gp130 subunit. In cattle (Bos taurus), LIF binds to the LIF receptor (LIFR) in association with gp130, activating JAK/STAT3, MAPK, and PI3K signaling pathways that regulate cell survival, differentiation, immune modulation, and tissue repair. Bovine LIF plays important roles in reproductive biology, particularly in endometrial function, embryo implantation, and early embryonic development, making it highly relevant to fertility and reproductive management in dairy and beef production systems. LIF is also involved in hematopoiesis, neural cell survival, and modulation of inflammatory responses during infections such as mastitis and respiratory disease, where STAT3-driven signaling can influence tissue remodeling and immune regulation. Dysregulated LIF expression may contribute to fibrosis or tumor progression in certain contexts. As both a reproductive and immunomodulatory cytokine, bovine LIF is important in studies of fertility, embryo culture systems, stem cell biology, and cytokine network regulation. Characterization of bovine LIF supports veterinary research aimed at improving reproductive efficiency, understanding inflammatory disease mechanisms, and advancing regenerative and translational applications relevant to livestock and comparative medicine.
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