Bovine IL-1 beta Polyclonal Antibody

Catalog Number:: KP1109B
Availability:: In stock
Application:: ELISA, ELISpot, Flow Cytometry, Neutralization, Western Blot
Host:: Rabbit
100% Homology:: Bos indicus (zebu), Bos javanicus (banteng), Bos taurus (cattle)
Label:: Unconjugated

The Bovine IL-1 beta polyclonal antibody is unlabeled and has been qualified for use in ELISA and Western blot applications. It is the capture antibody in the Kingfisher Biotech Bovine IL-1 beta ELISA. The Bovine IL-1 beta antibody was produced in rabbits and is antigen-affinity purified. The reactivity by species is: (Bovine IL-1beta - Strong) (Canine IL-1beta - None) (Caprine IL-1beta - Strong) (Dolphin IL-1beta - Weak) (Equine IL-1beta - None) (Feline IL-1beta - None) (Ferret IL-1beta - None) (Guinea Pig IL-1beta - Weak) (Human IL-1beta - Weak) (Mouse IL-1beta - None) (Ovine IL-1beta - Moderate) (Rabbit IL-1beta - None) (Swine IL-1beta - None) (Turkey IL-1beta - None). For research use only.

Bovine Interleukin-1 Beta (IL-1β) is a potent pro-inflammatory cytokine produced primarily by activated macrophages, monocytes, and dendritic cells in cattle (Bos taurus) in response to microbial components or tissue injury. Synthesized as an inactive precursor (pro-IL-1β), it requires cleavage by caspase-1 within the inflammasome complex to become biologically active, after which it binds to the IL-1 receptor (IL-1R1) and activates NF-κB and MAPK signaling pathways to promote fever, leukocyte recruitment, endothelial activation, and acute-phase protein production. In bovine health, IL-1β plays a central role in inflammatory responses associated with economically significant diseases such as mastitis, bovine respiratory disease (BRD), metritis, lameness, and enteric infections, where it contributes to both pathogen clearance and inflammatory tissue damage. Elevated IL-1β expression in the mammary gland is closely linked to neutrophil recruitment and severity of intramammary infection. As a biomarker of innate immune activation, bovine IL-1β is widely used in studies of vaccine responses, immune modulation, and disease pathogenesis. In veterinary and translational research, characterization of bovine IL-1β supports investigations into inflammasome biology, host-pathogen interactions, inflammatory regulation in large-animal systems, and development of strategies to mitigate excessive inflammation while preserving protective immunity.

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