Swine IFN lambda 3 (IL-28B) Polyclonal Antibody

Anti-swine IL-28B polyclonal antibody (catalog KP1295S) is made in rabbits, affinity-purified (swine IL-28B affinity chromatography) and supplied in PBS containing 0.09% NaN₃; it was raised against recombinant swine IL-28B (immunogen) and the calculated molecular weight of swine IL-28B is ~19.2 kDa. Store at 2-8°C (stable up to 12 months from date of receipt). Recommended working concentrations are Western blot 0.1-2 µg/mL and ELISA 1-5 µg/mL (optimize per assay); typical sandwich ELISA reagent pairings and suggested conditions are provided on the datasheet (capture antibody KP1295S; standard protein RP1202S-005; detection antibody KPB1296S; streptavidin-HRP AR0068-001; TMB substrate AR0133-002). It is commonly used for ELISA, ELISpot, flow cytometry, neutralization, and Western blot applications (users should validate and optimize conditions for each application). The product is made in the USA, supplied for research applications only, and is not intended for medicinal, diagnostic, or therapeutic use.

Swine interferon lambda 3 (IFN-λ3), also known as interleukin-28B (IL-28B), is a member of the type III interferon family and functions as a key antiviral cytokine that signals through the IFNLR1 (IL-28Rα)/IL-10R2 receptor complex, activating JAK/STAT pathways and inducing interferon-stimulated genes (ISGs) that restrict viral replication primarily at epithelial surfaces. In swine, IFN-λ3 plays a critical role in mucosal immunity within the respiratory and gastrointestinal tracts, major entry points for economically significant pathogens such as porcine reproductive and respiratory syndrome virus (PRRSV), swine influenza virus (SIV), porcine epidemic diarrhea virus (PEDV), transmissible gastroenteritis virus (TGEV), and porcine deltacoronavirus (PDCoV). Because type III interferons generate localized antiviral protection with less systemic inflammation than type I interferons, swine IFN-λ3 is likely essential for controlling viral spread while preserving tissue integrity and growth performance. As respiratory and enteric viral diseases substantially impact global pork production, swine IFN-λ3 (IL-28B) is highly relevant for understanding antiviral defense mechanisms, improving vaccine strategies, and developing immunomodulatory approaches to enhance herd health and biosecurity.

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