Rabbit Interferon-γ (IFN-γ) is a type II interferon cytokine that plays a central role in cell-mediated immunity and regulation of antimicrobial and inflammatory responses in rabbits (Oryctolagus cuniculus). IFN-γ is produced primarily by activated T helper 1 (Th1) cells, cytotoxic T lymphocytes, and natural killer (NK) cells following stimulation by intracellular pathogens or immune signaling molecules such as IL-12 and IL-18. Rabbit IFN-γ binds to the interferon-γ receptor (IFNGR1/IFNGR2) expressed on many immune and non-immune cells, activating intracellular signaling through the JAK–STAT pathway, particularly STAT1, which induces expression of numerous interferon-stimulated genes involved in antigen presentation, macrophage activation, and antimicrobial defense. In rabbits, IFN-γ is critical for activation of macrophages, enhancement of MHC class I and II expression, and control of intracellular pathogens including viruses, bacteria, and parasites. Rabbit IFN-γ is widely studied in rabbit models of infectious disease and immunology; for example, IFN-γ responses are commonly measured in rabbit models of Mycobacterium tuberculosis infection, where IFN-γ–producing T cells serve as an important indicator of cellular immune responses and disease progression.