Swine CCL11 (Eotaxin-1) Polyclonal Antibody

The Swine CCL11 (Eotaxin-1) polyclonal antibody is unlabeled and has been qualified for use in ELISA and Western blot applications. It is the capture antibody in the Kingfisher Biotech Swine CCL11 ELISA. The Swine CCL11 antibody was produced in rabbits and is antigen-affinity purified. The reactivity by species is: (Bovine CCL11 - None) (Caprine CCL11 - None) (Cynomolgus Monkey CCL11 - None) (Equine CCL11 - None) (Guinea Pig CCL11 - None) (Human CCL11 - None) (Mouse CCL11 - None) (Ovine CCL11 - None) (Rabbit CCL11 - None) (Swine CCL11 - Strong). For research use only.

Swine CCL11 (C-C motif chemokine ligand 11), also known as eotaxin-1, is a member of the CC chemokine family that regulates eosinophil recruitment and type 2-associated immune responses in pigs (Sus scrofa). CCL11 is produced primarily by epithelial cells, fibroblasts, endothelial cells, smooth muscle cells, and activated immune cells in response to Th2-associated cytokines such as IL-4 and IL-13, as well as inflammatory stimuli. It functions predominantly through the CCR3 receptor to promote chemotaxis and activation of eosinophils, and can also influence basophils and certain Th2 lymphocytes. In healthy swine, basal CCL11 expression is generally low, but levels may increase during parasitic infections-particularly helminth infections affecting the gastrointestinal or respiratory tract-as well as during allergic-type inflammation and mucosal immune activation. In veterinary and translational research, swine CCL11 is of interest in studies of parasite immunity, airway inflammation, gut barrier function, and Th2-biased immune responses, particularly given the physiological similarities between pigs and humans. Characterizing CCL11 expression in swine provides valuable insight into eosinophil biology, chemokine-mediated leukocyte trafficking, and regulation of type 2 inflammatory responses in both agricultural and biomedical research settings.

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