Rabbit Vascular Endothelial Growth Factor A (VEGF-A) is a member of the vascular endothelial growth factor (VEGF) family, which includes VEGF-A, VEGF-B, VEGF-C, VEGF-D, and placental growth factor (PlGF)—key regulators of angiogenesis, vascular permeability, and endothelial cell growth. In rabbits (Oryctolagus cuniculus), VEGF-A is produced by various cell types including endothelial cells, macrophages, fibroblasts, epithelial cells, and smooth muscle cells, particularly in response to hypoxia, inflammation, and tissue injury. VEGF-A exerts its biological effects primarily through binding to VEGF receptor-1 (VEGFR-1/Flt-1) and VEGF receptor-2 (VEGFR-2/KDR) on endothelial cells, activating intracellular signaling pathways such as MAPK/ERK, PI3K/AKT, and PLCγ, which promote endothelial cell proliferation, migration, vascular permeability, and formation of new blood vessels. In rabbits, VEGF-A plays important roles in vascular development, wound healing, and tissue regeneration, and it is also involved in placental vascularization and reproductive physiology. Because rabbits are widely used as experimental models in ophthalmology, cardiovascular research, and regenerative medicine, rabbit VEGF-A has been extensively studied in models of corneal neovascularization, retinal vascular disease, ischemic injury, and tissue repair, providing insights into angiogenesis and therapeutic strategies targeting VEGF signaling.