Ovine IL-22 Polyclonal Antibody

The Ovine IL-22 polyclonal antibody is unlabeled and has been qualified for use in ELISA and Western blot applications. It is the capture antibody in the Kingfisher Biotech Ovine IL-22 ELISA. The Ovine IL-22 antibody was produced in rabbits and is antigen-affinity purified. The reactivity by species is: (Caprine IL-22 - Moderate) (Chicken IL-22 - None) (Cynomolgus Monkey IL-22 - None) (Mouse IL-22 - None) (Ovine IL-22 - Strong) (Rabbit IL-22 - None) (Swine IL-22 - None). For research use only.

Ovine IL-22 (Interleukin-22) is a member of the IL-10 cytokine family that plays a critical role in mucosal immunity and epithelial barrier protection in sheep (Ovis aries). IL-22 is produced primarily by activated CD4⁺ T cells, including Th17- and Th22-like subsets, as well as by γδ T cells-which are prominent in ruminants-and innate lymphoid cells (ILC3s) in response to microbial infection and inflammatory stimulation. It signals through the IL-22 receptor complex (IL-22R1 and IL-10R2), expressed mainly on epithelial and stromal cells, activating downstream JAK/STAT pathways-particularly STAT3-to induce antimicrobial peptide production, enhance chemokine expression, promote epithelial cell proliferation, and support tissue repair. In healthy sheep, basal IL-22 expression is generally low but increases during bacterial, viral, and parasitic infections, especially at mucosal surfaces of the gastrointestinal, respiratory, and mammary tissues. Ovine IL-22 has been implicated in immune responses to gastrointestinal nematodes (e.g., Haemonchus contortus), Mycobacterium avium subspecies paratuberculosis, respiratory pathogens, and mastitis-causing bacteria. In veterinary and agricultural research, ovine IL-22 serves as a biomarker of mucosal immune activation and epithelial defense and is studied in the context of host-pathogen interactions, vaccine responses, and maintenance of barrier integrity in small ruminant health and production systems.

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