Guinea Pig IL-17A Polyclonal Antibody

Anti-guinea pig IL-17A polyclonal antibody (catalog KP1461GP) is made in rabbits, affinity-purified by guinea pig IL-17A affinity chromatography and supplied in PBS containing 0.09% NaN₃; it was raised against recombinant guinea pig IL-17A (immunogen) and the calculated molecular weight of guinea pig IL-17A is ~15.1 kDa. Store at 2-8°C (stable up to 12 months from date of receipt). Recommended working concentrations are Western blot 0.1-2 µg/mL and ELISA 1-5 µg/mL (optimize per assay); typical sandwich ELISA reagent pairings and suggested conditions are provided on the datasheet (capture antibody KP1461GP; standard protein RP1082GP-005; detection antibody KPB1462GP; streptavidin-HRP AR0068-001; TMB substrate AR0133-002). In cross-reactivity testing (ELISA) this antibody shows no reactivity to bovine, canine, caprine, cynomolgus monkey, dolphin, equine, feline, ferret, human, mouse, ovine, rabbit, rat, swine or zebrafish IL-17A. It is commonly used for ELISA, ELISpot, flow cytometry, neutralization, and Western blot applications (users should validate and optimize conditions for each application). The product is made in the USA, supplied for research applications only, and is not intended for medicinal, diagnostic, or therapeutic use.

Guinea pig IL-17A (Interleukin-17A) is a pro-inflammatory cytokine belonging to the IL-17 family that plays an important role in host defense and inflammatory responses in guinea pigs (Cavia porcellus). IL-17A is produced primarily by Th17 cells, as well as by γδ T cells and other innate lymphoid populations, in response to microbial infection and immune stimulation. It acts on epithelial, endothelial, and stromal cells to induce the expression of pro-inflammatory cytokines, chemokines (such as CXCL8), and antimicrobial peptides, thereby promoting neutrophil recruitment and enhancing mucosal and barrier immunity, particularly in the respiratory tract. In healthy guinea pigs, basal IL-17A expression is typically low, but levels increase during bacterial infection, allergic airway inflammation, and experimental immune challenge. In biomedical research, guinea pig IL-17A is especially relevant in models of tuberculosis (Mycobacterium tuberculosis), asthma, and allergic airway disease, where Th17-mediated responses contribute to neutrophilic inflammation and granuloma formation. Characterization of IL-17A in guinea pigs provides valuable insight into mucosal immunity, host-pathogen interactions, and inflammatory mechanisms in translational respiratory and infectious disease research.

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