Human GM-CSF Polyclonal Antibody

The Human GM-CSF polyclonal antibody is unlabeled and has been qualified for use in ELISA and Western blot applications. It is the capture antibody in the Kingfisher Human GM-CSF ELISA. The Human GM-CSF antibody was produced in rabbits and is antigen-affinity purified. The reactivity by species is: (Bovine GM-CSF - None) (Canine GM-CSF - None) (Caprine GM-CSF - None) (Chicken GM-CSF - None) (Cynomolgus Monkey GM-CSF - Weak) (Equine GM-CSF - None) (Feline GM-CSF - None) (Human GM-CSF - Strong) (Mouse GM-CSF - None) (Ovine GM-CSF - None) (Rabbit GM-CSF - Weak) (Rat GM-CSF - None) (Swine GM-CSF - None). For research use only.

Human GM-CSF (Granulocyte-Macrophage Colony-Stimulating Factor, CSF2) is a hematopoietic cytokine belonging to the colony-stimulating factor family, which also includes G-CSF (CSF3) and M-CSF (CSF1) that regulate the development, proliferation, and activation of myeloid immune cells. In humans (Homo sapiens), GM-CSF is produced by activated T lymphocytes, macrophages, endothelial cells, fibroblasts, and epithelial cells in response to infection, inflammatory cytokines, or immune stimulation. Human GM-CSF binds to the GM-CSF receptor (CSF2R) expressed on hematopoietic progenitor cells and mature myeloid cells, activating intracellular signaling pathways such as JAK/STAT, MAPK/ERK, and PI3K-AKT, which promote the proliferation and differentiation of granulocytes, macrophages, and dendritic cells, and enhance their antigen-presenting and inflammatory functions. In human health, GM-CSF plays an important role in host defense against infections, regulation of inflammatory responses, and development of immune cells involved in adaptive immunity. Dysregulation of GM-CSF signaling has been associated with inflammatory and autoimmune diseases, including rheumatoid arthritis and pulmonary alveolar proteinosis. Because of its ability to stimulate immune cell development and activation, GM-CSF is widely studied and used in clinical immunotherapy and vaccine research, including GM-CSF-based cancer vaccines designed to enhance dendritic cell activation and anti-tumor immune responses.

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