Bovine GM-CSF Polyclonal Antibody

The Bovine GM-CSF polyclonal antibody is unlabeled and has been qualified for use in ELISA and Western blot applications. It is the capture antibody in the Kingfisher Bovine GM-CSF ELISA. The Bovine GM-CSF antibody was produced in rabbits and is antigen-affinity purified. The reactivity by species is: (Bovine GM-CSF - Strong) (Canine GM-CSF - None) (Caprine GM-CSF - None) (Chicken GM-CSF - None) (Equine GM-CSF - None) (Feline GM-CSF - None) (Human GM-CSF - None) (Mouse GM-CSF - None) (Ovine GM-CSF - None) (Rabbit GM-CSF - None) (Rat GM-CSF - None) (Swine GM-CSF -None). For research use only.

Bovine GM-CSF (Granulocyte-Macrophage Colony-Stimulating Factor, CSF2) is a hematopoietic cytokine belonging to the colony-stimulating factor family, which also includes G-CSF (CSF3) and M-CSF (CSF1) that regulate the development, proliferation, and activation of myeloid immune cells. In cattle (Bos taurus), GM-CSF is produced by activated T lymphocytes, macrophages, endothelial cells, fibroblasts, and other stromal cells in response to infection, inflammatory cytokines, or immune stimulation. Bovine GM-CSF binds to the GM-CSF receptor (CSF2R) expressed on hematopoietic progenitor cells and mature myeloid cells, activating intracellular signaling pathways such as JAK/STAT, MAPK/ERK, and PI3K-AKT, which promote the proliferation and differentiation of granulocytes, macrophages, and dendritic cells, as well as enhance their functional activity in innate and adaptive immune responses. In bovine health, GM-CSF contributes to host defense against bacterial infections, particularly by regulating macrophage and neutrophil activity in tissues such as the mammary gland and respiratory tract. Bovine GM-CSF has also been studied in animal models of bovine tuberculosis caused by Mycobacterium bovis, where GM-CSF influences macrophage activation and antigen-presenting cell development, helping researchers understand cell-mediated immunity and vaccine responses to mycobacterial infections relevant to both livestock health and human tuberculosis research.

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