Canine CXCL10 (IP-10) Polyclonal Antibody

Catalog Number:: KP1663D
Availability:: In stock
Application:: ELISA, ELISpot, Flow Cytometry, Neutralization, Western Blot
Host:: Rabbit
100% Homology:: Canis lupus dingo (dingo), Canis lupus familiaris (dog)
Label:: Unconjugated

Product Description

The Canine CXCL10 (IP-10) polyclonal antibody is unlabeled and has been qualified for use in ELISA and Western blot applications. It is the capture antibody in the Kingfisher Canine CXCL10 ELISA. The Canine CXCL10 antibody was produced in rabbits and is antigen-affinity purified. The reactivity by species is: (Bovine CXCL10 - None) (Canine CXCL10 - Strong) (Caprine CXCL10 - None) (Cynomolgus Monkey CXCL10 - None) (Dolphin CXCL10 - None) (Equine CXCL10 - Weak) (Feline CXCL10 - Moderate) (Guinea Pig CXCL10 - None) (Human CXCL10 - None) (Mouse CXCL10 - Moderate) (Ovine CXCL10 - None) (Rabbit CXCL10 - Moderate) (Rat CXCL10 - None) (Swine CXCL10 - Strong). For research use only.

Properties

Storage Conditions	2°C to 8°C
Purification	Antigen-affinity
Country Of Origin	USA

Background Info

Canine CXCL10 (C-X-C motif chemokine ligand 10), also known as IP-10 (Interferon gamma-induced protein 10), is a proinflammatory chemokine belonging to the CXC chemokine family, which also includes CXCL9 (MIG) and CXCL11 (I-TAC) that regulate T-cell recruitment during antiviral and inflammatory immune responses. In dogs (Canis lupus familiaris), CXCL10 is produced by macrophages, dendritic cells, epithelial cells, endothelial cells, and fibroblasts in response to interferon-γ (IFN-γ), viral infection, or inflammatory cytokines. CXCL10 signals primarily through the chemokine receptor CXCR3, which is expressed on activated T lymphocytes, natural killer (NK) cells, and other immune cells, promoting chemotaxis and activation of these cells at sites of infection or inflammation. In canine health, CXCL10 contributes to immune responses against viral, bacterial, and parasitic pathogens, and elevated CXCL10 expression has been observed in inflammatory and immune-mediated diseases, including canine leishmaniasis, where recruitment of Th1-type T cells is important for parasite control. Dogs also serve as comparative animal models for human infectious and immune-mediated diseases, and canine leishmaniasis is widely studied as a model for human visceral leishmaniasis, where CXCL10-mediated recruitment of CXCR3⁺ T cells is associated with protective cell-mediated immunity and disease progression, making canine CXCL10 relevant for studies of host-pathogen interactions, immune regulation, and therapeutic development.

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