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Feline CXCL10 (IP-10) Polyclonal Antibody
- Catalog Number:
- KP1770F
- Availability:
- In stock
- Application:
- ELISA, ELISpot, Flow Cytometry, Neutralization, Western Blot
- Host:
- Rabbit
- 100% Homology:
- Acinonyx jubatus (cheetah), Felis catus (domestic cat), Lynx canadensis (Canada lynx), Lynx pardinus (Spanish lynx), Panthera leo (lion), Panthera pardus (leopard), Panthera tigris altaica (Amur tiger), Panthera uncia (snow leopard), Puma concolor (puma)
- Label:
- Unconjugated
- The Feline CXCL10 (IP-10) polyclonal antibody is unlabeled and has been qualified for use in ELISA and Western blot applications. It is the capture antibody in the Kingfisher Feline CXCL10 ELISA. The Feline CXCL10 antibody was produced in rabbits and is antigen-affinity purified. The reactivity by species is: (Bovine CXCL10 - None) (Canine CXCL10 - Weak) (Caprine CXCL10 - None) (Cynomolgus Monkey CXCL10 - None) (Dolphin CXCL10 - None) (Equine CXCL10 - None) (Feline CXCL10 - Strong) (Ferret CXCL10 - None) (Guinea Pig CXCL10 - None) (Human CXCL10 - None) (Mouse CXCL10 - None) (Ovine CXCL10 - None) (Rabbit CXCL10 - None) (Rat CXCL10 - None) (Swine CXCL10 - Weak). For research use only.
| Storage Conditions | 2°C to 8°C |
| Purification | Antigen-affinity |
| Country Of Origin | USA |
- Feline CXCL10 (C-X-C motif chemokine ligand 10), also known as IP-10 (Interferon gamma-induced protein 10), is a proinflammatory chemokine belonging to the CXC chemokine family, which also includes CXCL9 (MIG) and CXCL11 (I-TAC) that regulate T-cell recruitment during antiviral and inflammatory immune responses. In cats (Felis catus), CXCL10 is produced by macrophages, dendritic cells, epithelial cells, endothelial cells, and fibroblasts in response to interferon-γ (IFN-γ), viral infection, or inflammatory cytokines. CXCL10 signals primarily through the chemokine receptor CXCR3, which is expressed on activated T lymphocytes, natural killer (NK) cells, and other immune cells, promoting chemotaxis and activation of these cells at sites of infection or inflammation. In feline health, CXCL10 is involved in immune responses to viral infections such as feline immunodeficiency virus (FIV) and feline leukemia virus (FeLV), where interferon-driven chemokine signaling helps recruit antiviral immune cells to infected tissues. Cats also serve as important comparative animal models for human viral and immune-mediated diseases; for example, FIV infection in cats is widely used as a model for human HIV/AIDS, where CXCL10-mediated recruitment of CXCR3⁺ T cells contributes to immune activation and viral pathogenesis. In addition, feline infectious peritonitis (FIP) caused by feline coronavirus is used as a model for severe immune-mediated viral inflammation, where CXCL10 expression is associated with T-cell infiltration and cytokine-driven pathology, making feline CXCL10 relevant for studies of antiviral immunity, immune dysregulation, and inflammatory disease mechanisms.
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