Bovine PD-L1 Polyclonal Antibody

Catalog Number:: KP1917B
Availability:: In stock
Application:: ELISA, ELISpot, Flow Cytometry, Neutralization, Western Blot
Host:: Rabbit
100% Homology:: Bison bison bison (American buffalo), Bos indicus (zebu), Bos mutus (wild yak), Bos taurus (cattle)
Label:: Unconjugated

The Bovine PD-L1 polyclonal antibody is unlabeled and has been qualified for use in ELISA and Western blot applications. It is the capture antibody in the Kingfisher Bovine PD-L1 ELISA. The Bovine PD-L1 antibody was produced in rabbits and is antigen-affinity purified. The reactivity by species is: (Bovine PD-L1 - Strong) (Canine PD-L1 - None) (Rabbit PD-L1 - None). For research use only.

Bovine Programmed Death-Ligand 1 (PD-L1) (also known as CD274 or B7-H1) is an immune checkpoint protein that plays an important role in regulating T cell activation and immune tolerance in cattle (Bos taurus). PD-L1 is expressed on antigen-presenting cells such as macrophages and dendritic cells, as well as epithelial cells, endothelial cells, and some tumor or infected cells, and interacts with its receptor PD-1 (Programmed Death-1, CD279) on activated T lymphocytes. Engagement of PD-L1 with PD-1 delivers inhibitory signals that suppress T cell proliferation, cytokine production, and cytotoxic activity, helping to maintain immune homeostasis and prevent excessive inflammatory responses. In cattle, PD-L1 signaling has been associated with immune regulation during chronic infectious diseases, including bovine leukemia virus (BLV) infection, bovine tuberculosis caused by Mycobacterium bovis, and Johne's disease caused by Mycobacterium avium subsp. paratuberculosis, where increased PD-L1 expression can contribute to T cell exhaustion and reduced pathogen clearance. PD-L1 is also involved in controlling inflammatory responses during infection and tissue damage. Because immune checkpoint pathways influence host immunity and pathogen persistence, bovine PD-L1 is an important target of study in veterinary immunology, chronic infection research, and development of immunotherapeutic or vaccine strategies aimed at improving disease resistance in cattle.

Choose a size

Please choose a size to see price

RELATED MEDIA