Ferret IL-22 Polyclonal Antibody

The Ferret IL-22 polyclonal antibody is unlabeled and has been qualified for use in ELISA and Western blot applications. It is the capture antibody in the Kingfisher Ferret IL-22 ELISA. The Ferret IL-22 antibody was produced in rabbits and is antigen-affinity purified. The reactivity by species is: (Bat IL-22 - None) (Bovine IL-22 - None) (Caprine IL-22 - None) (Chicken IL-22 - None) (Cynomolgus Monkey IL-22 - None) (Ferret IL-22 - Strong) (Mouse IL-22 - None) (Ovine IL-22 - None) (Rabbit IL-22 - None) (Swine IL-22 - None). For research use only.

Ferret IL-22 (Interleukin-22) is a member of the IL-10 cytokine family that plays a key role in mucosal immunity and epithelial barrier protection in ferrets (Mustela putorius furo). IL-22 is produced primarily by activated CD4⁺ T cells, including Th17- and Th22-like populations, as well as by innate lymphoid cells (ILC3s) in response to microbial infection and inflammatory stimulation. It signals through the IL-22 receptor complex (IL-22R1 and IL-10R2), which is expressed mainly on epithelial and stromal cells, activating downstream JAK/STAT pathways-particularly STAT3-to induce antimicrobial peptide production, enhance chemokine expression, promote epithelial cell proliferation, and support tissue repair. In healthy ferrets, basal IL-22 expression is generally low but increases during bacterial, viral, and fungal infections, especially at mucosal surfaces of the respiratory and gastrointestinal tracts. In biomedical research, ferret IL-22 is particularly relevant in respiratory disease models such as influenza and SARS-CoV-2, where it contributes to epithelial defense and tissue regeneration while influencing inflammatory responses. Characterization of IL-22 in ferrets provides insight into mucosal immune regulation, host-pathogen interactions, and the balance between protective immunity and immunopathology in a widely used model of human respiratory infection.

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