Bovine CTLA-4 Polyclonal Antibody

Catalog Number:: KP1972B
Availability:: In stock
Application:: ELISA, ELISpot, Flow Cytometry, Neutralization, Western Blot
Host:: Rabbit
100% Homology:: Bison bison bison (American buffalo), Bos grunniens (domestic yak), Bos indicus (zebu), Bos mutus (wild yak), Bos taurus (cattle), Bubalus bubalis (water buffalo), Bubalus carabanensis (carabao)
Label:: Unconjugated

The Bovine CTLA-4 polyclonal antibody is unlabeled and has been qualified for use in ELISA and Western blot applications. It is the capture antibody in the Kingfisher Bovine CTLA-4 ELISA. The Bovine CTLA-4 antibody was produced in rabbits and is antigen-affinity purified. The reactivity by species is: (Bovine CTLA-4 - Strong) (Cynomolgus Monkey CTLA-4 - None) (Human CTLA-4 - None) (Rabbit CTLA-4 - None) (Swine CTLA-4 - Weak). For research use only.

Bovine CTLA-4 (Cytotoxic T-Lymphocyte-Associated Protein 4, also known as CD152) is an immune checkpoint receptor belonging to the immunoglobulin superfamily that plays a critical role in the negative regulation of T-cell activation in cattle (Bos taurus). CTLA-4 is primarily expressed on activated CD4⁺ and CD8⁺ T lymphocytes and regulatory T cells (Tregs) following antigen stimulation. It functions by binding to the costimulatory ligands CD80 (B7-1) and CD86 (B7-2) on antigen-presenting cells such as dendritic cells, macrophages, and B cells, competing with the activating receptor CD28 for these ligands. Through this interaction, CTLA-4 transmits inhibitory signals that reduce T-cell proliferation, cytokine production, and immune activation, helping to maintain immune homeostasis and prevent excessive inflammation. In bovine immunology, CTLA-4 plays an important role in regulating immune responses to viral, bacterial, and parasitic infections, as well as in controlling immune-mediated inflammation during diseases affecting cattle. Because immune checkpoint pathways are essential for balancing immune activation and tolerance, bovine CTLA-4 is studied in veterinary immunology, infectious disease research, and vaccine response studies, contributing to improved understanding of T-cell regulation and immune modulation in livestock health.

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