Flying Fox Bat (Pteropus species) CXCL10 (C-X-C motif chemokine ligand 10), also known as IP-10 (Interferon gamma–induced protein 10), is a proinflammatory chemokine belonging to the CXC chemokine family, which also includes CXCL9 (MIG) and CXCL11 (I-TAC) that regulate T-cell recruitment during antiviral immune responses. In flying fox bats, CXCL10 is produced by macrophages, dendritic cells, endothelial cells, epithelial cells, and other tissue cells in response to interferon-γ (IFN-γ), viral infection, or inflammatory cytokines. CXCL10 primarily signals through the chemokine receptor CXCR3, which is expressed on activated T lymphocytes, natural killer (NK) cells, and other immune cells, promoting chemotaxis and activation of these cells at sites of infection or inflammation. Flying fox bats are natural reservoirs for several zoonotic viruses, including Hendra virus and Nipah virus, and CXCL10 likely contributes to coordinating antiviral immune responses and recruitment of cytotoxic immune cells during infection. Studying CXCL10 in flying fox bats helps researchers understand bat antiviral immunity and host–pathogen interactions, including mechanisms that allow bats to control viral infections while limiting excessive inflammatory pathology, providing insights relevant to emerging infectious disease and zoonotic virus research.