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Bovine Erythropoietin (EPO) Polyclonal Antibody - Biotinylated
- Catalog Number:
- KPB1584B
- Availability:
- In stock
- Application:
- ELISA, ELISpot
- Host:
- Rabbit
- 100% Homology:
- Bison bison bison (American buffalo), Bos grunniens (domestic yak), Bos indicus (zebu), Bos mutus (wild yak), Bos taurus (cattle)
- Label:
- Biotin
- Biotinylated Anti-bovine EPO polyclonal antibody (catalog KPB1584B) is a biotinylated, made-in-rabbits reagent, affinity-purified by bovine EPO affinity chromatography and supplied in PBS containing 0.09% NaN₃; it was raised against recombinant bovine EPO (immunogen) and the calculated molecular weight of bovine EPO is ~18.4 kDa. Store at 2-8°C (stable up to 12 months from date of receipt). The antibody is supplied for ELISA (recommended 0.05-0.5 µg/mL; optimize per assay) and typical sandwich ELISA reagent pairings and suggested conditions are provided on the datasheet (capture antibody KP1583B-100; standard protein RP1275B-005; detection antibody KPB1584B; streptavidin-HRP AR0068-001; TMB substrate AR0133-002). In cross-reactivity testing (ELISA) this antibody shows strong reactivity to canine, equine, feline, mouse, rabbit and swine EPO. It is commonly used for ELISA and ELISpot. The product is made in the USA, supplied for research applications only, and is not intended for medicinal, diagnostic, or therapeutic use.
| Storage Conditions | 2°C to 8°C |
| Purification | Antigen-affinity |
| Country Of Origin | USA |
- Feline Erythropoietin (EPO) is a glycoprotein hormone belonging to the type I cytokine family that regulates erythropoiesis, the production of red blood cells. In cats (Felis catus), erythropoietin is produced primarily by peritubular interstitial cells in the kidney, with smaller amounts produced in the liver, in response to hypoxia or reduced oxygen-carrying capacity of the blood. Feline EPO binds to the erythropoietin receptor (EPOR) on erythroid progenitor cells in the bone marrow, activating signaling pathways such as JAK2-STAT5, PI3K-AKT, and MAPK, which promote survival, proliferation, and differentiation of erythroid precursor cells into mature red blood cells. In feline health, erythropoietin is essential for maintaining normal hematocrit and oxygen delivery to tissues, and insufficient EPO production is a major contributor to anemia associated with chronic kidney disease (CKD), a common condition in aging cats. Cats also serve as clinical models for studying anemia of chronic kidney disease, and research on feline erythropoietin has contributed to understanding the pathophysiology of renal anemia and the therapeutic use of recombinant erythropoietin or EPO-stimulating agents to manage anemia in both veterinary and human medicine.
50 ug
Price: $400.00
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