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Ovine IL-1 beta Polyclonal Antibody - Biotinylated
- Catalog Number:
- KPB1754V
- Availability:
- In stock
- Application:
- ELISA, ELISpot
- Host:
- Rabbit
- 100% Homology:
- Ovis aries (sheep), Pseudois nayaur (bharal)
- Label:
- Biotin
- The Ovine IL-1 beta polyclonal antibody is labeled and has been qualified for use in ELISA. It is the detection antibody in the Kingfisher Ovine IL-1 beta ELISA. The Ovine IL-1 beta antibody was produced in rabbits and is antigen-affinity purified. The reactivity by species is: (Bovine IL-1beta - Moderate) (Canine IL-1beta - None) (Caprine IL-1beta - Strong) (Cynomolgus Monkey - None) (Dolphin IL-1beta - None) (Equine IL-1beta - None) (Feline IL-1beta - None) (Ferret IL-1beta - None) (Guinea Pig IL-1beta - None) (Human IL-1beta - None) (Ovine IL-1beta - Strong) (Rabbit IL-1beta - None) (Swine IL-1beta - None) (Turkey IL-1beta - None). For research use only.
| Storage Conditions | 2°C to 8°C |
| Purification | Antigen-affinity |
| Country Of Origin | USA |
- Ovine Interleukin-1 Beta (IL-1β) is a potent pro-inflammatory cytokine produced primarily by activated macrophages, monocytes, and dendritic cells in sheep (Ovis aries) in response to infection, tissue injury, or inflammatory stimuli. Synthesized as an inactive precursor (pro-IL-1β), it is cleaved into its active form by caspase-1 within inflammasome complexes-most notably the NLRP3 inflammasome-and signals through the IL-1 receptor type 1 (IL-1R1), activating NF-κB and MAPK pathways that promote fever, leukocyte recruitment, endothelial activation, and acute-phase protein production. In ovine health, IL-1β plays a central role in inflammatory conditions associated with mastitis, pneumonia, foot rot, enteric infections, parasitic infestations, and viral diseases such as ovine progressive pneumonia (maedi-visna), where excessive IL-1β production can contribute to tissue damage and chronic inflammation. Elevated IL-1β expression is also observed in the mammary gland during intramammary infection and serves as a marker of disease severity. As a biomarker of innate immune activation, ovine IL-1β is important for evaluating vaccine responses and immune status in flock management. In veterinary and translational research, characterization of ovine IL-1β supports studies of inflammasome biology, host-pathogen interactions in small ruminants, inflammatory regulation, and development of targeted anti-inflammatory strategies relevant to both animal health and comparative immunology.
50 ug
Price: $400.00
RELATED MEDIA
CITATIONS
Takahashi Y, Takahashi T, Usuda H, Carter S, Fee EL, Furfaro L, Chemtob S, Olson DM, Keelan JA, Kallapur S, Kemp MW. Pharmacological blockade of the interleukin-1 receptor suppressed Escherichia coli lipopolysaccharide-induced neuroinflammation in preterm fetal sheep. Am J Obstet Gynecol MFM. 2023 Nov;5(11):101124. doi: 10.1016/j.ajogmf.2023.101124. Epub 2023 Aug 18. PMID: 37597799.
Application: ELISA
Sample Type: Amniotic Fliuid, Fetal Lung Tissue