Bovine IFN alpha A Polyclonal Antibody - Biotinylated

The Bovine IFN alpha A polyclonal antibody is labeled and has been qualified for use in ELISA. It is the detection antibody in the Kingfisher Bovine IFN alpha A ELISA. The Bovine IFN alpha A antibody was produced in rabbits and is antigen-affinity purified. The reactivity by species is: (Bovine IFN alpha A - Strong) (Canine IFN alpha - None) (Caprine IFN alpha - Weak) (Chicken IFN alpha - None) (Equine IFN alpha 1 - None) (Feline IFN alpha - None) (Human IFN alpha - None) (Mouse IFN alpha - None ) (Ovine IFN alpha A - Weak) (Swine IFN alpha 1 - None). For research use only.

Bovine Interferon-Alpha A (IFN-αA) is a type I interferon subtype produced primarily by plasmacytoid dendritic cells and virus-infected cells in cattle (Bos taurus), where it plays a central role in early innate antiviral defense. Upon binding to the type I interferon receptor complex (IFNAR1/IFNAR2), bovine IFN-αA activates the JAK/STAT signaling pathway, leading to induction of interferon-stimulated genes (ISGs) that inhibit viral replication, enhance antigen presentation, and promote activation of natural killer (NK) cells and adaptive immune responses. In bovine health, IFN-αA is critically involved in host responses to economically significant viral infections such as bovine viral diarrhea virus (BVDV), bovine herpesvirus-1 (IBR), bovine respiratory syncytial virus (BRSV), foot-and-mouth disease virus (FMDV), and other components of the bovine respiratory disease (BRD) complex. Altered or suppressed IFN-α responses-such as immune evasion by BVDV-can contribute to viral persistence and increased disease severity. As both a biomarker and functional mediator of antiviral immunity, bovine IFN-αA is important in vaccine evaluation, antiviral strategy development, and immunopathogenesis studies. In translational research, characterization of bovine IFN-αA supports comparative studies of type I interferon biology, viral immune evasion mechanisms, and large-animal models of respiratory and systemic viral infection relevant to both veterinary and human medicine.

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Price: $400.00

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