Feline CCL2 (C-C motif chemokine ligand 2, also known as monocyte chemoattractant protein-1, MCP-1) is a pro-inflammatory chemokine that plays a key role in recruitment and activation of monocytes, macrophages, and memory T cells during immune responses in cats (Felis catus). CCL2 signals primarily through the CCR2 receptor, activating downstream pathways that promote leukocyte migration, cytokine production, and coordination of innate and adaptive immune responses at sites of infection or tissue injury. In feline health, CCL2 is particularly relevant in inflammatory and infectious diseases such as feline infectious peritonitis (FIP) caused by feline coronavirus, feline immunodeficiency virus (FIV) infection, chronic kidney disease, and inflammatory bowel disease, where elevated CCL2 expression contributes to macrophage recruitment and local inflammatory pathology. While CCL2-mediated immune cell trafficking is essential for pathogen defense and tissue repair, dysregulated or excessive expression can drive chronic inflammation and immune-mediated tissue damage. As a biomarker of monocyte/macrophage recruitment and inflammatory activation, feline CCL2 is widely studied in investigations of host–pathogen interactions, immune regulation, and disease pathogenesis. Characterization of feline CCL2 supports veterinary research into inflammatory disease mechanisms and provides comparative insight into chemokine-driven immune responses relevant to human infectious and inflammatory disorders.