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Equine IL-2 Polyclonal Antibody
- Catalog Number:
- PB0050E
- Availability:
- In stock
- Application:
- ELISA, ELISpot, Flow Cytometry, Neutralization, Western Blot
- Host:
- Goat
- 100% Homology:
- Equus asinus (ass), Equus caballus (horse), Equus przewalskii (Przewalski's horse), Equus quagga (Plains zebra)
- Label:
- Unconjugated
- The Equine IL-2 polyclonal antibody is unlabeled and has been qualified for use in ELISA and Western blot applications. It is the capture antibody in the Kingfisher Biotech Equine IL-2 ELISA. The Equine IL-2 polyclonal antibody was produced in goats and is antigen-affinity purified. The reactivity by species is: (Bovine IL-2 - None) (Canine IL-2 - Weak) (Chicken IL-2 - None) (Equine IL-2 - Strong) (Feline IL-2 - None) (Human IL-2 - None) (Mouse IL-2 - None) (Swine IL-2 - None). For research use only.
| Storage Conditions | 2°C to 8°C |
| Purification | Antigen-affinity |
| Country Of Origin | USA |
- Equine IL-2 (Interleukin-2) is a central T cell-derived cytokine that regulates lymphocyte proliferation, differentiation, and immune homeostasis in horses (Equus caballus). IL-2 is produced primarily by activated CD4⁺ and CD8⁺ T lymphocytes following antigen recognition and costimulatory signaling, and it functions through the IL-2 receptor complex (IL-2Rα/CD25, IL-2Rβ, and the common γ chain) to promote clonal expansion of antigen-specific T cells, enhance cytotoxic T lymphocyte and natural killer (NK) cell activity, and support development and maintenance of regulatory T cells (Tregs). In healthy horses, basal IL-2 expression is generally low but increases during infection, vaccination, and immune stimulation. Altered IL-2 responses have been associated with equine herpesvirus (EHV) infection, equine influenza, strangles (Streptococcus equi), equine infectious anemia virus (EIAV), and immune-mediated inflammatory diseases. Horses serve as important natural models for viral respiratory disease, chronic inflammatory airway disease (equine asthma), and lentiviral infection (EIAV as a model for HIV). In veterinary and comparative medicine research, equine IL-2 is widely used as a biomarker of T cell activation and cell-mediated immunity and is studied to evaluate vaccine efficacy, host-pathogen interactions, and immune regulation in equine health.
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