Swine IL-8 Polyclonal Antibody

Catalog Number:: PB0143S
Availability:: In stock
Application:: ELISA, ELISpot, Flow Cytometry, Neutralization, Western Blot
Host:: Rabbit
100% Homology:: Phacochoerus africanus (Common warthog), Sus scrofa (pig)
Label:: Unconjugated

Product Description

The Swine IL-8 (CXCL8) polyclonal antibody is unlabeled and has been qualified for use in ELISA and Western blot applications. It is the capture antibody in the Kingfisher Biotech Swine IL-8 ELISA. The Swine IL-8 polyclonal antibody was produced in rabbits and is antigen-affinity purified. The reactivity by species is: (Bovine IL-8 - Strong) (Canine IL-8 - Moderate) (Catfish IL-8 - None) (Chicken IL-8 - None) (Dolphin IL-8 - Strong) (Equine IL-8 - Moderate) (Feline IL-8 - Strong) (Guinea Pig IL-8 - None) (Human IL-8 - None) (Ovine IL-8 - Strong) (Rabbit IL-8 - None) (Swine IL-8 - Strong) (Turkey IL-8 - None). For research use only.

Properties

Storage Conditions	2°C to 8°C
Purification	Antigen-affinity
Country Of Origin	USA

Background Info

Swine Interleukin-8 (IL-8), also known as CXCL8, is a potent pro-inflammatory chemokine that plays a central role in innate immune responses in pigs (Sus scrofa domesticus) by mediating neutrophil chemotaxis, activation, and migration to sites of infection or tissue injury. Produced by macrophages, respiratory and intestinal epithelial cells, endothelial cells, and other immune cells in response to microbial products and inflammatory cytokines, swine IL-8 signals primarily through CXCR1 and CXCR2 receptors to promote rapid neutrophil recruitment and amplification of inflammatory responses. Elevated IL-8 expression is observed in economically significant diseases such as porcine reproductive and respiratory syndrome (PRRS), swine influenza, Mycoplasma hyopneumoniae infection, Actinobacillus pleuropneumoniae pneumonia, enteric infections, and bacterial sepsis, where excessive neutrophilic inflammation can contribute to lung injury, reduced growth performance, and systemic pathology. As a biomarker, IL-8 is widely used to assess immune activation, vaccine response, and disease severity in swine production systems. In translational research, pigs serve as valuable large-animal models for human respiratory disease, sepsis, trauma, and inflammatory disorders due to their physiological and immunological similarities to humans; thus, characterization of swine IL-8 supports studies of neutrophil-driven immunopathology, cytokine network regulation, and development of targeted anti-inflammatory and immunomodulatory therapies relevant to both veterinary and human medicine.

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