Swine IFN gamma Polyclonal Antibody

The Swine IFN gamma polyclonal antibody is unlabeled and has been qualified for use in ELISA and Western blot applications. It is the capture antibody in the Kingfisher Biotech Swine IFN gamma ELISA. The Swine IFN gamma polyclonal antibody was produced in rabbits and is antigen-affinity purified. The reactivity by species is: (Bovine IFN-gamma - Moderate) (Canine IFN-gamma - None) (Caprine IFN-gamma - Moderate) (Chicken IFN-gamma - None) (Cynomolgus Monkey IFN-gamma - Weak) (Dolphin IFN-gamma - Moderate) (Equine IFN-gamma - Weak) (Feline IFN-gamma - Weak) (Human IFN-gamma - Moderate) (Mouse IFN-gamma - Weak) (Ovine IFN-gamma - Moderate) (Rabbit IFN-gamma - Moderate) (Swine IFN-gamma - Strong) (Zebrafish IFN-gamma1-1 - None) (Zebrafish IFN-gamma1-2 - None). For research use only.

Swine Interferon-γ (IFN-γ) is a type II interferon cytokine that plays a central role in cell-mediated immunity and regulation of antimicrobial and inflammatory responses in pigs (Sus scrofa). IFN-γ is produced primarily by activated T helper 1 (Th1) cells, cytotoxic T lymphocytes, and natural killer (NK) cells following stimulation by intracellular pathogens or immune signaling molecules such as IL-12 and IL-18. Swine IFN-γ binds to the interferon-γ receptor (IFNGR1/IFNGR2) expressed on many immune and non-immune cells, activating intracellular signaling through the JAK-STAT pathway, particularly STAT1, which induces the expression of numerous interferon-stimulated genes involved in antigen presentation, macrophage activation, and antimicrobial defense. In pigs, IFN-γ is critical for activation of macrophages, enhancement of MHC class I and II expression, and control of intracellular pathogens, including viruses, bacteria, and parasites. Swine IFN-γ is widely studied in veterinary immunology and translational research, particularly in porcine models of infectious disease; for example, IFN-γ responses are commonly measured in studies of African swine fever virus (ASFV) infection and vaccine development, where IFN-γ-producing T cells serve as an important indicator of protective cellular immune responses.

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