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Bovine IL-17A Polyclonal Antibody
- Catalog Number:
- PB0274B
- Availability:
- In stock
- Application:
- ELISA, ELISpot, Flow Cytometry, Neutralization, Western Blot
- Host:
- Rabbit
- 100% Homology:
- Bos indicus (zebu), Bos javanicus (banteng), Bos taurus (cattle)
- Label:
- Unconjugated
- The Bovine IL-17A polyclonal antibody is unlabeled and has been qualified for use in ELISA and Western blot applications. It is the capture antibody in the Kingfisher Biotech Bovine IL-17A ELISA. The Bovine IL-17A polyclonal antibody was produced in rabbits and is antigen-affinity purified. The reactivity by species is: (Bovine IL-17A - Strong) (Canine IL-17A - Weak) (Caprine IL-17A - Moderate) (Cynomolgus Monkey IL-17A - Weak) (Dolphin IL-17A - Strong) (Equine IL-17A - None) (Feline IL-17A - Moderate) (Ferret IL-17A - Weak) (Guinea Pig IL-17A - Weak) (Human IL-17A - Weak) (Mouse IL-17A - Weak) (Ovine IL-17A - Strong) (Rabbit IL-17A - Weak) (Rat IL-17A - Weak) (Swine IL-17A - Strong). For research use only.
| Storage Conditions | 2°C to 8°C |
| Purification | Antigen-affinity |
| Country Of Origin | USA |
- Bovine IL-17A (Interleukin-17A) is a pro-inflammatory cytokine belonging to the IL-17 family that plays a critical role in host defense and inflammatory responses in cattle (Bos taurus). IL-17A is produced primarily by Th17 cells, as well as by γδ T cells-which are abundant in ruminants-and other innate lymphoid cell populations in response to microbial infection and inflammatory stimulation. It acts on epithelial, endothelial, and stromal cells to induce expression of pro-inflammatory cytokines, chemokines (such as CXCL8), and antimicrobial peptides, thereby promoting neutrophil recruitment and enhancing mucosal and barrier immunity. In healthy cattle, basal IL-17A expression is generally low, but levels increase during bacterial and fungal infections, mastitis, respiratory disease, enteric infections, and parasitic challenges. IL-17A has been implicated in immune responses to pathogens such as Mycobacterium bovis, bovine respiratory disease complex agents, and gastrointestinal nematodes. In veterinary and agricultural research, bovine IL-17A serves as an important biomarker of Th17-mediated immunity and neutrophilic inflammation, providing insight into host-pathogen interactions, vaccine responses, and inflammatory disease mechanisms in cattle.
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CITATIONS
Wattegedera SR, Thomson J, Coulter L, Wood A, McLean RK, Hill H, Cunnea C, Snedden K, Percival A, Palarea-Albaladejo J, Entrican G, Longbottom D, Griffiths DJ, McInnes CJ. Evaluation of Immunogenicity of an Orf Virus Vector-Based Vaccine Delivery Platform in Sheep. Vaccines (Basel). 2025 Jun 11;13(6):631. doi: 10.3390/vaccines13060631. PMID: 40573962; PMCID: PMC12197756.
Application: ELISA
Sample Type: Supernatants (PBMCs)
Corripio-Miyar Y, Hayward AD, Lemon H, Bal X, Cunnea C, Kenyon F, Pilkington JG, Pemberton JM, Nussey DH, McNeilly TN. T-helper cell phenotypes are repeatable, positively correlated, and associated with helminth infection in wild Soay sheep. Discov Immunol. 2025 Feb 8;4(1):kyae017. doi: 10.1093/discim/kyae017. PMID: 39963298; PMCID: PMC11832277.
Application: ELISA
Sample Type: Supernatants (Ovine whole blood stimulation)
Maina TW, Grego EA, Broderick S, Sacco RE, Narasimhan B, McGill JL. Immunization with a mucosal, post-fusion F/G protein-based polyanhydride nanovaccine protects neonatal calves against BRSV infection. Front Immunol. 2023 Jun 9;14:1186184. doi: 10.3389/fimmu.2023.1186184. PMID: 37359514; PMCID: PMC10289034.
Application: ELISA
Sample Type: Supernatants