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Feline IFN gamma Polyclonal Antibody
- Catalog Number:
- PB0281F
- Availability:
- In stock
- Application:
- ELISA, ELISpot, Flow Cytometry, Neutralization, Western Blot
- Host:
- Rabbit
- 100% Homology:
- Acinonyx jubatus (cheetah), Felis catus (domestic cat), Prionailurus bengalensis (leopard cat), Prionailurus viverrinus (fishing cat), Puma concolor (puma)
- Label:
- Unconjugated
- The Feline IFN gamma polyclonal antibody is unlabeled and has been qualified for use in ELISA and Western blot applications. It is the capture antibody in the Kingfisher Biotech Feline IFN gamma ELISA. The Feline IFN gamma polyclonal antibody was produced in rabbits and is antigen-affinity purified. The reactivity by species is: (Bovine IFN-gamma - None) (Canine IFN-gamma - Weak) (Caprine IFN-gamma - None) (Chicken IFN-gamma - None) (Cynomolgus Monkey IFN-gamma - None) (Dolphin IFN-gamma - None) (Equine IFN-gamma - None) (Feline IFN-gamma - Strong) (Human IFN-gamma - None) (Mouse IFN-gamma - None) (Ovine IFN-gamma - None) (Rabbit IFN-gamma - None) (Swine IFN-gamma - None) (Zebrafish IFN-gamma1-1 - None) (Zebrafish IFN-gamma1-2 - None). For research use only.
| Storage Conditions | 2°C to 8°C |
| Purification | Antigen-affinity |
| Country Of Origin | USA |
- Feline Interferon-Gamma (IFN-γ) is a type II interferon produced primarily by activated CD4⁺ and CD8⁺ T lymphocytes as well as natural killer (NK) cells in cats (Felis catus), where it plays a central role in cell-mediated (Th1-type) immunity. IFN-γ signals through the IFN-γ receptor complex (IFNGR1/IFNGR2), activating JAK/STAT1 pathways and inducing genes involved in macrophage activation, enhanced antigen presentation via upregulation of MHC class I and II molecules, and promotion of cytotoxic T-cell responses. In feline health, IFN-γ is critical for host defense against intracellular pathogens and viral infections such as feline leukemia virus (FeLV), feline immunodeficiency virus (FIV), feline infectious peritonitis (FIP; feline coronavirus), Toxoplasma gondii, and mycobacterial infections, where balanced Th1 responses contribute to pathogen control while dysregulation may influence immunopathology or chronic inflammation. Clinically, IFN-γ expression levels serve as indicators of cellular immune competence and disease progression. In animal model research, cats serve as important natural models for human retroviral infection (FIV as a model for HIV), coronavirus-associated immune dysregulation (FIP as a model for severe systemic coronavirus disease), and certain immune-mediated and oncologic conditions. Characterization of feline IFN-γ supports studies of antiviral immunity, T-cell function, vaccine development, and comparative Th1 immune regulation, enhancing translational understanding of cell-mediated immune responses relevant to both veterinary and human medicine.
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