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Canine IFN gamma Polyclonal Antibody
- Catalog Number:
- PB0386D
- Availability:
- In stock
- Application:
- ELISA, ELISpot, Flow Cytometry, Neutralization, Western Blot
- Host:
- Rabbit
- 100% Homology:
- Canis lupus dingo (dingo), Canis lupus familiaris (dog), Nyctereutes procyonoides (raccoon dog), Vulpes lagopus (Arctic fox), Vulpes vulpes (red fox)
- Label:
- Unconjugated
- The Canine IFN gamma polyclonal antibody is unlabeled and has been qualified for use in ELISA and Western blot applications. It is the capture antibody in the Kingfisher Biotech Canine IFN gamma ELISA. The Canine IFN gamma polyclonal antibody was produced in rabbits and is antigen-affinity purified. The reactivity by species is: (Bovine IFN-gamma - Weak) (Canine IFN-gamma - Strong) (Chicken IFN-gamma - None) (Dolphin IFN-gamma - Weak) (Human IFN-gamma - Weak) (Rabbit IFN-gamma - None) (Swine IFN-gamma - None). For research use only.
| Storage Conditions | 2°C to 8°C |
| Purification | Antigen-affinity |
| Country Of Origin | USA |
- Canine Interferon-Gamma (IFN-γ) is a type II interferon produced primarily by activated CD4⁺ and CD8⁺ T lymphocytes and natural killer (NK) cells in dogs (Canis lupus familiaris), where it plays a central role in cell-mediated (Th1-type) immunity against intracellular pathogens. IFN-γ signals through the IFN-γ receptor complex (IFNGR1/IFNGR2), activating JAK/STAT1 pathways and inducing genes involved in macrophage activation, enhanced antigen presentation via upregulation of MHC class I and II molecules, nitric oxide production, and promotion of cytotoxic T-cell responses. In canine health, IFN-γ is critical for defense against pathogens such as Leishmania infantum, Mycobacterium spp., canine distemper virus, and certain tick-borne intracellular organisms, and its expression levels are often associated with protective Th1 immune responses and vaccine efficacy. Dysregulated or insufficient IFN-γ responses can contribute to chronic infection, immune-mediated disease, or altered inflammatory balance. In translational research, dogs serve as valuable spontaneous models for human infectious diseases (e.g., leishmaniasis), autoimmune conditions, and certain cancers, and characterization of canine IFN-γ supports studies of T-cell function, immune modulation, vaccine development, and comparative cell-mediated immunity relevant to both veterinary medicine and human health.
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