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Swine CCL2 (MCP-1) Polyclonal Antibody - Biotinylated
- Catalog Number:
- PBB0089S
- Availability:
- In stock
- Application:
- ELISA, ELISpot
- Host:
- Rabbit
- 100% Homology:
- Sus scrofa (pig)
- Label:
- Biotin
- The Swine CCL2 (MCP-1) polyclonal antibody is labeled and has been qualified for use in ELISA. It is the detection antibody in the Kingfisher Biotech Swine CCL2 ELISA. The Swine CCL2 polyclonal antibody was produced in rabbits and is antigen-affinity purified. The reactivity by species is: (Bovine CCL2 - Strong) (Canine CCL2 - Strong) (Equine CCL2 - Strong) (Guinea Pig CCL2 - Weak) (Mouse CCL2 - Weak) (Rabbit CCL2 - None) (Swine CCL2 - Strong). For research use only.
| Storage Conditions | 2°C to 8°C |
| Purification | Antigen-affinity |
| Country Of Origin | USA |
- Swine CCL2 (C-C motif chemokine ligand 2, also known as monocyte chemoattractant protein-1, MCP-1) is a pro-inflammatory chemokine that plays an important role in recruitment and activation of monocytes, macrophages, and memory T cells during immune responses in pigs (Sus scrofa domesticus). CCL2 signals primarily through the CCR2 receptor, activating intracellular pathways that promote leukocyte migration, cytokine production, and coordination of innate and adaptive immune responses at sites of infection, inflammation, or tissue injury. In swine health, CCL2 is particularly relevant in respiratory and systemic infectious diseases, including porcine reproductive and respiratory syndrome virus (PRRSV), swine influenza, and bacterial pneumonia, where monocyte and macrophage recruitment to the lungs influences both antiviral defense and inflammatory lung pathology. CCL2 is also involved in inflammatory responses in tissues such as the gut and joints, contributing to immune cell infiltration and tissue remodeling. While CCL2-mediated immune cell trafficking supports pathogen clearance and tissue repair, excessive or prolonged expression can contribute to chronic inflammation and tissue damage. Because pigs are widely used as large-animal models for human infectious, inflammatory, and cardiovascular diseases, characterization of swine CCL2 supports research into chemokine-mediated immune regulation, host-pathogen interactions, and development of anti-inflammatory or immunomodulatory therapies relevant to both veterinary and human medicine.
50 ug
Price: $400.00
CITATIONS
Ma J, Van der Weken H, Hermans L, Dierick M, Cox E, Devriendt B. Enterotoxigenic Escherichia coli heat-labile enterotoxin induces cell death and disrupts effector functions in porcine monocytes. Vet Res. 2025 Jul 6;56(1):138. doi: 10.1186/s13567-025-01540-w. PMID: 40619401; PMCID: PMC12232694.
Application: ELISA
Sample Type: Monocyte Supernatant
van Maanen JC, Bach FC, Snuggs JW, Ito K, Wauben MHM, Le Maitre CL, Tryfonidou MA. Explorative Study of Modulatory Effects of Notochordal Cell-Derived Extracellular Vesicles on the IL-1β-Induced Catabolic Cascade in Nucleus Pulposus Cell Pellets and Explants. JOR Spine. 2025 Jan 29;8(1):e70043. doi: 10.1002/jsp2.70043. PMID: 39881783; PMCID: PMC11775941.
Application: ELISA
Sample Type: Supernatants