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Bovine CCL2 (MCP-1) Polyclonal Antibody - Biotinylated
- Catalog Number:
- PBB0093B
- Availability:
- In stock
- Application:
- ELISA, ELISpot
- Host:
- Rabbit
- 100% Homology:
- Bison bison bison (American buffalo), Bos indicus (zebu), Bos mutus (wild yak), Bos taurus (cattle)
- Label:
- Biotin
- The Bovine CCL2 (MCP-1) polyclonal antibody is labeled and has been qualified for use in ELISA and Western blot applications. It is the capture antibody in the Kingfisher Biotech Bovine CCL2 ELISA. The Bovine CCL2 polyclonal antibody was produced in rabbits and is antigen-affinity purified. The reactivity by species is: (Dolphin CCL2 - Strong) (Ovine/Caprine CCL2 - Strong). For research use only.
- Dolphin CCL2 - Strong Ovine/Caprine CCL2 - Strong
| Storage Conditions | 2°C to 8°C |
| Purification | Antigen-affinity |
| Country Of Origin | USA |
- Bovine CCL2 (C-C motif chemokine ligand 2, also known as monocyte chemoattractant protein-1, MCP-1) is a pro-inflammatory chemokine that plays a central role in recruitment and activation of monocytes, macrophages, and memory T cells during immune responses in cattle (Bos taurus). CCL2 signals primarily through the CCR2 receptor, triggering intracellular signaling pathways that promote leukocyte migration, cytokine production, and coordination of innate and adaptive immune responses at sites of infection or tissue injury. In bovine health, CCL2 is particularly important in inflammatory conditions such as mastitis, where it mediates recruitment of monocytes and macrophages to infected mammary tissue, as well as in respiratory diseases associated with the bovine respiratory disease complex (BRDC) and infections such as Mycobacterium bovis. While CCL2-driven immune cell recruitment supports pathogen clearance and tissue repair, excessive or prolonged expression can contribute to tissue damage and chronic inflammation. As a biomarker of monocyte/macrophage recruitment and inflammatory activation, bovine CCL2 is widely studied in investigations of host-pathogen interactions, immune responses to bacterial and viral infections, and vaccine efficacy. Characterization of bovine CCL2 supports veterinary research aimed at improving disease resistance, understanding inflammatory disease mechanisms, and enhancing health and productivity in cattle.
50 ug
Price: $400.00
CITATIONS
Nguyen M, Battistoni CM, Babiak PM, Liu JC, Panitch A. Chondroitin Sulfate/Hyaluronic Acid-Blended Hydrogels Suppress Chondrocyte Inflammation under Pro-Inflammatory Conditions. ACS Biomater Sci Eng. 2024 May 13;10(5):3242-3254. doi: 10.1021/acsbiomaterials.4c00200. Epub 2024 Apr 17. PMID: 38632852; PMCID: PMC11094685.
Application: ELISA
Sample Type: Supernatants (Chondrocytes)
Takahashi Y, Takahashi T, Usuda H, Carter S, Fee EL, Furfaro L, Chemtob S, Olson DM, Keelan JA, Kallapur S, Kemp MW. Pharmacological blockade of the interleukin-1 receptor suppressed Escherichia coli lipopolysaccharide-induced neuroinflammation in preterm fetal sheep. Am J Obstet Gynecol MFM. 2023 Nov;5(11):101124. doi: 10.1016/j.ajogmf.2023.101124. Epub 2023 Aug 18. PMID: 37597799.
Application: ELISA
Sample Type: Amniotic Fliuid, Fetal Lung Tissue
Takahashi Y, Saito M, Usuda H, Takahashi T, Watanabe S, Hanita T, Sato S, Kumagai Y, Koshinami S, Ikeda H, Carter S, Fee EL, Furfaro L, Chemtob S, Keelan J, Olson D, Yaegashi N, Newnham JP, Jobe AH, Kemp MW. Direct administration of the non-competitive interleukin-1 receptor antagonist rytvela transiently reduced intrauterine inflammation in an extremely preterm sheep model of chorioamnionitis. PLoS One. 2021 Sep 24;16(9):e0257847. doi: 10.1371/journal.pone.0257847. PMID: 34559862; PMCID: PMC8462743.
Application: ELISA
Sample Type: Amniotic Fluid/Cord Plasma