Bovine IFN gamma Polyclonal Antibody - Biotinylated

Catalog Number:: PBB0267B
Availability:: In stock
Application:: ELISA, ELISpot
Host:: Rabbit
100% Homology:: Bos frontalis (gayal), Bos taurus (cattle)
Label:: Biotin

Product Description

The Bovine IFN gamma polyclonal antibody is labeled and has been qualified for use in ELISA. It is the detection antibody in the Kingfisher Biotech Bovine IFN gamma ELISA. The Bovine IFN gamma polyclonal antibody was produced in rabbits and is antigen-affinity purified. The reactivity by species is: (Bovine IFN gamma - Strong) (Chicken IFN gamma - Weak) (Equine IFN gamma - Moderate) (Feline IFN gamma - Moderate) (Rabbit IFN gamma - Weak) (Swine IFN gamma - Moderate). For research use only.

Properties

Storage Conditions	2°C to 8°C
Purification	Antigen-affinity
Country Of Origin	USA

Background Info

Bovine Interferon-Gamma (IFN-γ) is a type II interferon produced primarily by activated CD4⁺ and CD8⁺ T lymphocytes and natural killer (NK) cells in cattle (Bos taurus), where it plays a central role in cell-mediated (Th1-type) immunity against intracellular pathogens. IFN-γ signals through the IFN-γ receptor complex (IFNGR1/IFNGR2), activating JAK/STAT1 pathways and inducing genes involved in macrophage activation, enhanced antigen presentation via upregulation of MHC class I and II molecules, nitric oxide production, and promotion of cytotoxic T-cell responses. In bovine health, IFN-γ is critically important for defense against economically significant intracellular infections such as Mycobacterium bovis (bovine tuberculosis), Mycobacterium avium subsp. paratuberculosis (Johne's disease), Brucella abortus, and certain viral pathogens including bovine viral diarrhea virus (BVDV). Measurement of antigen-specific IFN-γ release forms the basis of widely used diagnostic assays for bovine tuberculosis and serves as an indicator of cellular immune activation and vaccine responsiveness. Dysregulated or insufficient IFN-γ responses can contribute to chronic infection, pathogen persistence, and altered disease progression. In veterinary and translational research, characterization of bovine IFN-γ supports studies of host-pathogen interactions, Th1/Th2 immune balance, vaccine efficacy, and immune correlates of protection, while also providing a valuable large-animal model for understanding cell-mediated immunity relevant to human tuberculosis and other intracellular infectious diseases.

Choose a size

Price: $400.00

RELATED MEDIA