Bovine IL-36 Receptor Antagonist (IL-36RA) Polyclonal Antibody - Biotinylated

The Bovine IL-36 Receptor Antagonist (IL-1F5) polyclonal antibody is labeled and has been qualified for use in ELISA. It is the detection antibody in the Kingfisher Biotech Bovine IL-36 Receptor Antagonist ELISA. The Bovine IL-36 Receptor Antagonist polyclonal antibody was produced in rabbits and is antigen-affinity purified. For research use only.

Bovine Interleukin-36 Receptor Antagonist (IL-36Ra) is an anti-inflammatory cytokine that regulates IL-36-mediated immune responses in cattle (Bos taurus). IL-36Ra is a member of the IL-1 cytokine family and functions as a natural inhibitor of the IL-36 signaling pathway by binding to the IL-36 receptor (IL-36R, also known as IL1RL2) without activating it, thereby preventing proinflammatory cytokines such as IL-36α, IL-36β, and IL-36γ from initiating downstream signaling. Through this mechanism, bovine IL-36Ra suppresses activation of intracellular pathways including NF-κB and MAPK, helping to limit production of inflammatory mediators and regulate immune responses at epithelial barrier tissues such as the skin, respiratory tract, and gastrointestinal mucosa. In cattle, IL-36Ra contributes to maintaining immune homeostasis and controlling excessive inflammatory responses during infection or tissue injury. In cell culture, recombinant bovine IL-36Ra is commonly used to inhibit IL-36-induced inflammatory signaling in epithelial and immune cells, allowing researchers to study cytokine regulation, epithelial-immune interactions, and modulation of inflammatory pathways in vitro. Bovine IL-36Ra is also studied in veterinary immunology and translational research to better understand mechanisms of epithelial inflammation, host-pathogen interactions, and immune regulation relevant to livestock health and comparative inflammatory disease biology.

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Price: $400.00

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