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Guinea Pig TNF alpha Polyclonal Antibody - Biotinylated
- Catalog Number:
- PBB0452GP
- Availability:
- In stock
- Application:
- ELISA, ELISpot
- Host:
- Goat
- 100% Homology:
- Cavia porcellus (domestic guinea pig)
- Label:
- Biotin
- The Guinea Pig TNF alpha polyclonal antibody is labeled and has been qualified for use in ELISA. It is the detection antibody in the Kingfisher Biotech Guinea Pig TNF alpha ELISA. The Guinea Pig TNF alpha polyclonal antibody was produced in goats and is antigen-affinity purified. The reactivity by species is: (Bovine TNF-alpha - None) (Canine TNF-alpha - None) (Dolphin TNF-alpha - None) (Equine TNF-alpha - None) (Feline TNF-alpha - None) (Guinea Pig TNF-alpha - Strong) (Human TNF-alpha - None) (Mouse TNF-alpha - Weak) (Ovine TNF-alpha - Weak) (Rabbit TNF-alpha - Weak) (Swine TNF-alpha - None). For research use only.
| Storage Conditions | 2°C to 8°C |
| Purification | Antigen-affinity |
| Country Of Origin | USA |
- Guinea Pig Tumor Necrosis Factor Alpha (TNF-α) (also known as TNF or cachectin) is a proinflammatory cytokine that plays a central role in innate immune responses, inflammation, and host defense against pathogens in guinea pigs (Cavia porcellus). TNF-α is a member of the tumor necrosis factor (TNF) superfamily, which includes related cytokines such as TNF-β (lymphotoxin-α), Fas ligand (FasL), CD40 ligand (CD40L), and TRAIL, proteins that regulate immune signaling, apoptosis, and inflammatory pathways. In guinea pigs, TNF-α is primarily produced by activated macrophages, monocytes, dendritic cells, and T lymphocytes in response to infection, endotoxin exposure, or tissue injury. TNF-α exerts its biological effects by binding to TNF receptors TNFR1 (p55) and TNFR2 (p75), activating intracellular signaling pathways including NF-κB, MAPK, and caspase-mediated pathways, which regulate cytokine production, immune cell activation, apoptosis, and inflammatory responses. In guinea pigs, TNF-α is particularly important in immune responses to intracellular bacterial infections such as Mycobacterium tuberculosis, for which guinea pigs serve as a well-established animal model of human tuberculosis due to their similar disease pathology and granuloma formation. TNF-α contributes to macrophage activation, granuloma maintenance, and containment of mycobacterial infection, although excessive TNF signaling can also contribute to tissue inflammation and pathology. Because guinea pigs are widely used in infectious disease, immunology, and tuberculosis research, characterization of guinea pig TNF-α supports studies of cytokine regulation, host-pathogen interactions, and inflammatory responses relevant to both veterinary and human health.
50 ug
Price: $400.00
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