Swine CXCL10 (C-X-C motif chemokine ligand 10), also known as IP-10 (Interferon gamma–induced protein 10), is a proinflammatory chemokine belonging to the CXC chemokine family, which also includes CXCL9 (MIG) and CXCL11 (I-TAC) that regulate T-cell recruitment during antiviral and inflammatory immune responses. In pigs (Sus scrofa), CXCL10 is produced by macrophages, dendritic cells, epithelial cells, endothelial cells, and fibroblasts in response to interferon-γ (IFN-γ), viral infection, or inflammatory cytokines. CXCL10 signals primarily through the chemokine receptor CXCR3, which is expressed on activated T lymphocytes, natural killer (NK) cells, and other immune cells, promoting chemotaxis and activation of these cells at sites of infection or inflammation. In swine health, CXCL10 plays an important role in immune responses to viral infections such as porcine reproductive and respiratory syndrome virus (PRRSV) and swine influenza virus, where interferon-driven chemokine signaling helps recruit antiviral T cells to infected lung tissues. Because pigs share significant physiological and immunological similarities with humans, they are also used as translational animal models for respiratory and infectious diseases, and CXCL10 expression is studied to better understand interferon-mediated immune responses, lung inflammation, and host–pathogen interactions relevant to both veterinary and human medicine.