Bovine IL-13 Recombinant Protein

Catalog Number:: RP0002B
Availability:: In stock
Application:: Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
100% Homology:: Bos indicus (zebu), Bos taurus (cattle), Bubalus bubalis (water buffalo)

Product Description

Bovine IL-13 (catalog RP0002B) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~12.6 kDa, 112 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology across cattle, water buffalo, and zebu. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use. It is commonly used in immunology and cell-biology research to study IL-13 signaling and Th2 responses, mucus production and airway hyperresponsiveness, alternative (M2) macrophage activation, fibrosis and epithelial cell biology, and to support eosinophil and B-cell functions (including IgE class switching); typical experimental uses include cell-culture stimulation and dosing studies, ELISA and neutralization assays, flow-cytometry controls, cytokine signaling assays, and antibody generation/validation.

Specifications

Amino Acid Sequence	SPVPSATALK ELIEELVNIT QNQKVPLCNG SMVWSLNLTS SMYCAALDSL ISISNCSVIQ RTKKMLNALC PHKPSAKQVS SEYVRDTKIE VAQFLKDLLR HSRIVFRNER FN (112)
Endotoxin	Naturally endotoxin-free

Properties

Storage Conditions	-20°C
Molecular Weight	12.6kDa
Purity	>98% as visualized by SDS-PAGE analysis.
Country Of Origin	USA

Background Info

Bovine Interleukin-13 (IL-13) is a Th2-associated cytokine produced primarily by activated CD4⁺ T helper 2 (Th2) cells and other type 2 immune cells in cattle (Bos taurus), where it plays a central role in regulating allergic-type inflammation, mucosal immunity, and tissue remodeling. IL-13 signals through receptor complexes composed of IL-13Rα1 and IL-4Rα, activating JAK/STAT6 pathways that drive alternative macrophage activation, modulation of pro-inflammatory cytokine production, mucus secretion, and IgE-associated immune responses. In bovine health, IL-13 is particularly important in responses to parasitic infections such as gastrointestinal nematodes and lungworms, where Th2 polarization supports parasite clearance and tissue repair, but may also contribute to fibrosis or chronic inflammation if dysregulated. IL-13 is also implicated in allergic and inflammatory respiratory conditions, mastitis-associated immune modulation, and shaping the Th1/Th2 balance during infections such as bovine viral diarrhea virus (BVDV) and other pathogens. As a biomarker of type 2 immune polarization, bovine IL-13 is relevant in vaccine development, host-parasite interaction studies, and evaluation of immune resilience in production systems. In veterinary and comparative research, characterization of bovine IL-13 supports investigations into mucosal immunity, fibrotic responses, cytokine network regulation, and development of strategies to enhance disease resistance while minimizing inflammatory pathology in cattle.

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