Swine CXCL10 (IP-10) Recombinant Protein

Catalog Number:: RP0004S
Availability:: In stock
Application:: Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
100% Homology:: Sus scrofa (pig)

Swine CXCL10 (IP-10) (catalog RP0004S) is a yeast-derived chemokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS containing at least 0.1% carrier protein. The protein is ~9.3 kDa, 82 amino acids long (full sequence provided), and >98% pure by SDS-PAGE. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use. It is commonly used in immunology and cell-biology research to study chemokine signaling, leukocyte chemoattraction and migration (particularly CXCR3⁺ T cells and NK cells), inflammation and antiviral responses; typical experimental uses include chemotaxis and cell-migration assays, cell-culture stimulation, ELISA and neutralization assays, receptor-binding studies, flow-cytometry controls, and antibody generation/validation.

Amino Acid Sequence	PLSRTVRCTC IKISDRPVNP RSLEKLEMIP ASQSCPHVEI IATMKKNGEK RCLNPESKTI KNLLKAISKE RSKRSPRTQR EA (82)
Endotoxin	Naturally endotoxin-free

Storage Conditions	-20°C
Molecular Weight	9.3 kDa
Purity	>98% as visualized by SDS-PAGE analysis.
Country Of Origin	USA

Swine CXCL10 (C-X-C motif chemokine ligand 10), also known as IP-10 (Interferon gamma-induced protein 10), is a proinflammatory chemokine belonging to the CXC chemokine family, which also includes CXCL9 (MIG) and CXCL11 (I-TAC) that regulate T-cell recruitment during antiviral and inflammatory immune responses. In pigs (Sus scrofa), CXCL10 is produced by macrophages, dendritic cells, epithelial cells, endothelial cells, and fibroblasts in response to interferon-γ (IFN-γ), viral infection, or inflammatory cytokines. CXCL10 signals primarily through the chemokine receptor CXCR3, which is expressed on activated T lymphocytes, natural killer (NK) cells, and other immune cells, promoting chemotaxis and activation of these cells at sites of infection or inflammation. In swine health, CXCL10 plays an important role in immune responses to viral infections such as porcine reproductive and respiratory syndrome virus (PRRSV) and swine influenza virus, where interferon-driven chemokine signaling helps recruit antiviral T cells to infected lung tissues. Because pigs share significant physiological and immunological similarities with humans, they are also used as translational animal models for respiratory and infectious diseases, and CXCL10 expression is studied to better understand interferon-mediated immune responses, lung inflammation, and host-pathogen interactions relevant to both veterinary and human medicine.

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