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Swine CXCL11 (I-TAC) Recombinant Protein
- Catalog Number:
- RP0005S
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Sus scrofa (pig)
- Swine CXCL11 (catalog RP0005S) is a yeast-derived chemokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS containing at least 0.1% carrier protein. The protein is ~8.9 kDa, 79 amino acids long (full sequence provided), and >98% pure by SDS-PAGE. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use. It is commonly used in immunology and cell-biology research to study chemokine signaling, leukocyte chemoattraction and migration (particularly CXCR3⁺ T cells and NK cells), inflammation and antiviral responses; typical experimental uses include chemotaxis and cell-migration assays, cell-culture stimulation and dosing studies, ELISA and neutralization assays, receptor-binding studies, flow-cytometry controls, and antibody generation/validation.
| Amino Acid Sequence | FPMFKAGRCL CIGPGVKAVK VADIEKVSII HPSNNCDKTE VIVTLKAHKG RRCLNPKSKQ ANVIMKKVER MNFLRYQNV (79) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 8.9 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Swine CXCL11 (C-X-C motif chemokine ligand 11), also known as I-TAC (Interferon-inducible T-cell alpha chemoattractant), is a proinflammatory chemokine belonging to the CXC chemokine family, which also includes CXCL9 (MIG) and CXCL10 (IP-10) that regulate T-cell recruitment during antiviral and inflammatory immune responses. In pigs (Sus scrofa), CXCL11 is produced by macrophages, dendritic cells, epithelial cells, endothelial cells, and fibroblasts in response to interferon-γ (IFN-γ), viral infection, or inflammatory cytokines. CXCL11 signals primarily through the chemokine receptor CXCR3, expressed on activated T lymphocytes, natural killer (NK) cells, and other immune cells, promoting chemotaxis and activation of these cells at sites of infection or inflammation. In swine health, CXCL11 contributes to Th1-type immune responses against viral pathogens, including porcine reproductive and respiratory syndrome virus (PRRSV) and swine influenza virus, where recruitment of CXCR3⁺ T cells to lung tissues is important for antiviral defense. Because pigs share many physiological and immunological similarities with humans, they are also used as translational animal models for respiratory and infectious diseases, and CXCL11 is studied as part of the interferon-driven chemokine network that regulates T-cell trafficking, lung inflammation, and antiviral immunity in these models.
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