Swine CXCL11 (C-X-C motif chemokine ligand 11), also known as I-TAC (Interferon-inducible T-cell alpha chemoattractant), is a proinflammatory chemokine belonging to the CXC chemokine family, which also includes CXCL9 (MIG) and CXCL10 (IP-10) that regulate T-cell recruitment during antiviral and inflammatory immune responses. In pigs (Sus scrofa), CXCL11 is produced by macrophages, dendritic cells, epithelial cells, endothelial cells, and fibroblasts in response to interferon-γ (IFN-γ), viral infection, or inflammatory cytokines. CXCL11 signals primarily through the chemokine receptor CXCR3, expressed on activated T lymphocytes, natural killer (NK) cells, and other immune cells, promoting chemotaxis and activation of these cells at sites of infection or inflammation. In swine health, CXCL11 contributes to Th1-type immune responses against viral pathogens, including porcine reproductive and respiratory syndrome virus (PRRSV) and swine influenza virus, where recruitment of CXCR3⁺ T cells to lung tissues is important for antiviral defense. Because pigs share many physiological and immunological similarities with humans, they are also used as translational animal models for respiratory and infectious diseases, and CXCL11 is studied as part of the interferon-driven chemokine network that regulates T-cell trafficking, lung inflammation, and antiviral immunity in these models.