Swine IL-13 Recombinant Protein

Catalog Number:: RP0007S
Availability:: In stock
Application:: Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
100% Homology:: Sus scrofa (pig)

Product Description

Swine IL-13 (catalog RP0007S) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS containing at least 0.1% carrier protein. The protein is ~13.2 kDa, 120 amino acids long (full sequence provided), and >98% pure by SDS-PAGE. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use. It is commonly used in immunology and cell-biology research to study IL-13 signaling and Th2 responses, mucus production and airway hyperresponsiveness, alternative (M2) macrophage activation, fibrosis and epithelial cell biology, and to support eosinophil and B-cell functions; typical experimental uses include cell-culture stimulation and dosing studies, ELISA and neutralization assays, flow-cytometry controls, cytokine signaling assays, and antibody generation/validation.

Specifications

Amino Acid Sequence	LTCFGGLASP GPVPPHSTAL KELIEELVNI TQNQKTPLCN GSMVWSVNLT TSMYCAALES LINISDCSAI QKTQRMLSAL CSHKPPSEQV PGKHIRDTKI EVAQFVKDLL KHLRMIFRHG (120)
Endotoxin	Naturally endotoxin-free

Properties

Storage Conditions	-20°C
Molecular Weight	13.2kDa
Purity	>98% as visualized by SDS-PAGE analysis.
Country Of Origin	USA

Background Info

Swine Interleukin-13 (IL-13) is a Th2-associated cytokine produced primarily by activated CD4⁺ T helper 2 (Th2) cells and other type 2 immune populations in pigs (Sus scrofa domesticus), where it plays an important role in regulating mucosal immunity, alternative macrophage activation, and tissue remodeling. IL-13 signals through receptor complexes composed of IL-13Rα1 and IL-4Rα, activating JAK/STAT6 pathways that promote IgE-associated responses, mucus production, modulation of pro-inflammatory cytokine signaling, and support of wound healing processes. In swine health, IL-13 is particularly relevant in responses to gastrointestinal and respiratory parasitic infections, where Th2 polarization aids parasite clearance and mucosal repair. IL-13 may also influence immune regulation during viral infections such as porcine reproductive and respiratory syndrome virus (PRRSV) and swine influenza by shaping the balance between Th1 and Th2 responses. While protective in controlling inflammation and supporting tissue repair, excessive or prolonged IL-13 activity may contribute to airway remodeling or fibrotic changes. As a biomarker of type 2 immune activation, swine IL-13 is important in studies of vaccine efficacy, host-parasite interactions, and immune resilience in production systems. In translational research, pigs serve as valuable large-animal models due to physiological similarities to humans, and characterization of swine IL-13 supports comparative investigations into Th2-mediated inflammation, fibrosis, and cytokine-targeted therapeutic strategies.

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