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Bovine IL-15 Recombinant Protein
- Catalog Number:
- RP0009B
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Bos indicus (zebu), Bos mutus (wild yak), Bos taurus (cattle), Bubalus bubalis (water buffalo), Bubalus kerabau (carabao), Moschus berezovskii (Chinese forest musk deer)
- Bovine IL-15 (catalog RP0009B) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS containing at least 0.1% carrier protein. The protein is ~13.2 kDa, 114 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology across several species: cattle, zebu, wild yak, water buffalo, carabao, and Chinese forest musk deer. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use. It is commonly used in immunology and cell-biology research to study IL-15 signaling, NK-cell and CD8⁺ T-cell proliferation/survival, memory T-cell responses and cytokine biology; typical experimental uses include cell-culture stimulation and dosing studies, proliferation and cytotoxicity assays, ELISA and neutralization assays, flow-cytometry controls, and antibody generation/validation.
| Amino Acid Sequence | NWQYVINDLK TIEHLIQSIH MDATLYTESD AHPNCKVTAM QCFLLELRVI LHESKNATIY EIIENLTMLA NSNLSSIENK TELGCKECEE LEEKSIKEFL KSFVHIVQMF INTS (114) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 13.2 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Bovine Interleukin-15 (IL-15) is a cytokine that plays a key role in regulating innate and adaptive immune responses in cattle (Bos taurus). IL-15 is produced primarily by monocytes, macrophages, dendritic cells, and other non-lymphoid tissues in response to infection or inflammatory stimuli. Bovine IL-15 signals through a heterotrimeric receptor complex composed of IL-15Rα, IL-2/15Rβ (CD122), and the common γ chain (γc), activating intracellular signaling pathways including JAK1/3 and STAT3/5 that promote lymphocyte proliferation, survival, and activation. In cattle, IL-15 is particularly important for the development, maintenance, and activation of natural killer (NK) cells and memory CD8⁺ T cells, supporting cytotoxic responses against infected or abnormal cells. It also contributes to regulation of mucosal immunity and inflammatory responses during infection. Bovine IL-15 has been studied in the context of immune responses to important livestock pathogens such as Mycobacterium bovis, bovine viral diarrhea virus (BVDV), and Mycobacterium avium subsp. paratuberculosis. Due to its role in regulating cellular immunity and lymphocyte homeostasis, bovine IL-15 is widely investigated in veterinary immunology and translational research, including studies of vaccine development, host-pathogen interactions, and immune modulation relevant to cattle health and comparative biomedical research.
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