Swine IFN alpha 1 Recombinant Protein

Catalog Number:: RP0010S
Availability:: In stock
Application:: Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
100% Homology:: Sus scrofa (pig)

Swine IFN-α1 (catalog RP0010S) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile phosphate-buffered saline containing at least 0.1% carrier protein. The protein is ~19.0 kDa, 166 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to pig. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use. It is commonly used in immunology and cell-biology research to study interferon signaling and antiviral responses, induction of interferon-stimulated genes and antiviral states, and for antiviral/cytopathic-effect assays; typical experimental uses include cell-culture stimulation and dosing studies, ELISA and neutralization assays, receptor-binding studies, flow-cytometry controls, and antibody generation/validation.

Amino Acid Sequence	CDLPQTHSLA HTRALRLLAQ MRRISPFSCL DHRRDFGSPH EAFGGNQVQK AQAMALVHEM LQQTFQLFST EGSAAAWNES LLHQFCTGLD QQLRDLEACV MQGAGLEGTP LLEEDSILAV RKYFHRLTLY LQEKSYSPCA WEIVRAEVMR SFSSSRNLQD RLRKKE (166)
Endotoxin	Naturally endotoxin-free

Storage Conditions	-20°C
Molecular Weight	19.0 kDa
Purity	>98% as visualized by SDS-PAGE analysis.
Country Of Origin	USA

Swine Interferon-Alpha (IFN-α) is a type I interferon produced primarily by plasmacytoid dendritic cells and virus-infected cells in pigs (Sus scrofa domesticus), where it plays a central role in early innate antiviral defense. Upon binding to the type I interferon receptor complex (IFNAR1/IFNAR2), swine IFN-α activates JAK/STAT signaling pathways, leading to induction of interferon-stimulated genes (ISGs) that inhibit viral replication, enhance antigen presentation, and promote activation of natural killer (NK) cells and adaptive immune responses. IFN-α is critically involved in host responses to economically significant viral infections such as porcine reproductive and respiratory syndrome virus (PRRSV), swine influenza virus, African swine fever virus (ASFV), porcine epidemic diarrhea virus (PEDV), and classical swine fever virus (CSFV), where viral immune evasion strategies often target type I interferon pathways to enhance replication and persistence. The magnitude and timing of IFN-α responses can influence disease severity, viral shedding, and vaccine efficacy. In translational research, pigs serve as valuable large-animal models due to physiological and immunological similarities to humans, and characterization of swine IFN-α supports studies of respiratory viral pathogenesis, antiviral therapeutics, vaccine development, and comparative type I interferon biology relevant to both veterinary medicine and human infectious disease research.

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