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Bovine CXCL11 (I-TAC) Recombinant Protein
- Catalog Number:
- RP0016B
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Bison bison bison (American buffalo), Bos grunniens (domestic yak), Bos indicus (zebu), Bos javanicus (banteng), Bos mutus (wild yak), Bos taurus (cattle), Bubalus bubalis (water buffalo), Bubalus kerabau (carabao)
- Bovine CXCL11 (catalog RP0016B) is a yeast-derived chemokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS containing at least 0.1% carrier protein. The protein is ~8.8 kDa, 79 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology across several bovine species: cattle, American buffalo, zebu, banteng, carabao, wild yak, domestic yak, and water buffalo. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use. It is commonly used in immunology and cell-biology research to study chemokine signaling and leukocyte chemoattraction/migration (particularly CXCR3⁺ T cells and NK cells), inflammation and immune cell trafficking; typical experimental uses include chemotaxis and cell-migration assays, receptor-binding and signaling studies, cell-culture stimulation and dosing, ELISA and neutralization assays, flow-cytometry controls, and antibody generation/validation.
| Amino Acid Sequence | FPMFKGGRCL CIGPGVKAVK VADIEKVSII YPTNNCDKTE VIITLKTHKG QRCLNPKAKQ AKAIIKKVQR KNSEKYKNI (79) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 8.8 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Bovine CXCL11 (C-X-C motif chemokine ligand 11), also known as I-TAC (Interferon-inducible T-cell alpha chemoattractant), is a proinflammatory chemokine belonging to the CXC chemokine family, which also includes CXCL9 (MIG) and CXCL10 (IP-10) that regulate T-cell recruitment during antiviral and inflammatory immune responses. In cattle (Bos taurus), CXCL11 is produced by macrophages, dendritic cells, endothelial cells, epithelial cells, and fibroblasts in response to interferon-γ (IFN-γ), microbial infection, or inflammatory cytokines. CXCL11 signals through the chemokine receptor CXCR3, which is expressed on activated T lymphocytes, natural killer (NK) cells, and other immune cells, promoting chemotaxis and activation of these cells at sites of infection or inflammation. In bovine health, CXCL11 contributes to Th1-type immune responses against intracellular pathogens, including Mycobacterium bovis, the causative agent of bovine tuberculosis, where CXCL11-mediated recruitment of CXCR3⁺ T cells supports granuloma formation and cellular immune defense. Because bovine tuberculosis shares important immunopathological features with human tuberculosis, cattle are used as comparative animal models for tuberculosis research, and bovine CXCL11 is studied as part of the interferon-driven chemokine network involved in T-cell trafficking, host-pathogen interactions, and development of diagnostic and vaccine strategies.
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